Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.

Journal: Frontiers in immunology
PMID: 39735537

Abstract

BACKGROUND: Thyroid-associated orbitopathy (TAO) is an autoimmune inflammatory disorder of the orbital adipose tissue, primarily causing oxidative stress injury and tissue remodeling in the orbital connective tissue. Ferroptosis is a form of programmed cell death driven by the accumulation of reactive oxygen species (ROS), iron metabolism disorder, and lipid peroxidation. This study aims to identify and validate the optimal feature genes (OFGs) of ferroptosis with diagnostic and therapeutic potential in TAO orbital adipose tissue through bioinformatics analysis and to assess their correlation with disease-related immune cell infiltration.

Authors

  • Xuemei Li
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Chao Xiong
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Siyi Wang
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
  • Zhangjun Ren
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Qi Jin
    Department of Ophthalmology, The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Jinhai Yu
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Yunxiu Chen
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Puying Gan
    Department of Ophthalmology, The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Qihua Xu
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Yaohua Wang
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
  • Hongfei Liao
    School of Optometry, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.

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