Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.

Journal: Respiratory research
Published Date:

Abstract

RATIONALE: Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests that inflammatory processes may contribute to COPD risk independently of smoking. We hypothesized that inflammatory protein biomarkers in non-AATD COPD are associated with moderate-to-severe COPD in AATD individuals, after accounting for clinical factors.

Authors

  • Matthew Moll
    Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
  • Brian D Hobbs
    Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA; Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA.
  • Katherine A Pratte
    Department of Biostatistics, National Jewish Health, Denver, CO, 80206, USA.
  • Chengyue Zhang
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA, 02115, USA.
  • Auyon J Ghosh
    Division of Pulmonary and Critical Care Medicine, SUNY Upstate Medical Center, Syracuse, NY, 13210, USA.
  • Russell P Bowler
    Division of Pulmonary and Critical Care Medicine, University of Colorado, Denver, CO; Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO.
  • David A Lomas
    Division of Medicine, UCL Respiratory, Rayne Institute, University College London, London, UK.
  • Edwin K Silverman
    Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
  • Dawn L Demeo
    Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America.