AIMC Topic: Inflammation Mediators

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Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.

NPJ biofilms and microbiomes
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...

Prognosis modelling of adverse events for post-PCI treated AMI patients based on inflammation and nutrition indexes.

BMC cardiovascular disorders
OBJECTIVE: This study aimed to evaluate the predictive performance of inflammatory and nutritional indices for adverse cardiovascular events (ACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) using...

Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure.

Frontiers in immunology
The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to...

Large-Scale Multi-omic Analysis of COVID-19 Severity.

Cell systems
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from COVID-19-positive and COVID-19-negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associa...

ProIn-Fuse: improved and robust prediction of proinflammatory peptides by fusing of multiple feature representations.

Journal of computer-aided molecular design
A proinflammatory peptide (PIP) is a type of signaling molecules that are secreted from immune cells, which contributes to the first line of defense against invading pathogens. Numerous experiments have shown that PIPs play an important role in human...

Machine Learning to Understand the Immune-Inflammatory Pathways in Fibromyalgia.

International journal of molecular sciences
Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways may be involved. We examined serum interleuki...

Evaluation of Effect of Glucosamine-Chondroitin Sulfate, Tramadol, and Sodium Hyaluronic Acid on Expression of Cytokine Levels in Internal Derangement of Temporomandibular Joint.

The journal of contemporary dental practice
AIM: Evaluation of the effect of glucosamine-chondroitin combination, tramadol, and sodium hyaluronic acid in temporomandibular joint (TMJ) disorders and its impact on the expression of various cytokines such as IL-6, IL-1β, TNF-α, and PGE2.

Circulating betatrophin in relation to metabolic, inflammatory parameters, and oxidative stress in patients with type 2 diabetes mellitus.

Diabetes & metabolic syndrome
AIMS: Recently, it was suggested that betatrophin has a role in controlling pancreatic β cell proliferation and lipid metabolism, however, its role in human subjects has not been established yet. The predicting role of betatrophin and MDA along with ...