AIMC Topic: Inflammation Mediators

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Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency.

Respiratory research Jul 15, 2025
RATIONALE: Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests that inflammatory processes may contribute to COPD risk indepe...
Pulmonary Disease, Chronic Obstructive Male Middle Aged Inflammation Mediators alpha 1-Antitrypsin Deficiency alpha 1-Antitrypsin Humans Biomarkers Female Aged
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Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients.

Cardiovascular diabetology Jul 3, 2025
BACKGROUND: Coronary Heart Disease (CHD) and Non-Alcoholic Fatty Liver Disease (NAFLD) share overlapping pathogenic mechanisms including adipose tissue dysfunction, insulin resistance, and systemic inflammation mediated by adipokines. However, the sp...
Predictive Value of Tests Coronary Angiography Non-alcoholic Fatty Liver Disease Heart Disease Risk Factors Inflammation Mediators Adult Male Middle Aged Risk Assessment Humans Inflammation Retrospective Studies Female Coronary Disease Aged Machine Learning Biomarkers Prognosis
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Targeted metabolomics reveals bioactive inflammatory mediators from gut into blood circulation in children with NAFLD.

NPJ biofilms and microbiomes Jul 1, 2025
Altered gut metabolites are important for the inflammatory progression in children with NAFLD. Fecal and plasma samples were collected from 145 subjects including 53 non-alcoholic fatty liver (NAFL), 39 nonalcoholic steatohepatitis (NASH) and 53 obes...
Metabolome Non-alcoholic Fatty Liver Disease Chromatography, High Pressure Liquid Inflammation Mediators Child Feces Inflammation Gastrointestinal Microbiome Metabolomics Humans Female Male Adolescent
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Inflammation-related 5-hydroxymethylation signatures as markers for clinical presentations of coronary artery disease.

Cardiovascular diabetology Jun 23, 2025
BACKGROUND: Coronary angiography remains the gold standard for diagnosing coronary artery disease (CAD), but its invasive nature limits its applicability for widespread screening. Identifying non-invasive molecular markers could improve CAD classific...
Female Reproducibility of Results Aged Male Middle Aged Humans Machine Learning Biomarkers Prognosis Cell-Free Nucleic Acids Non-ST Elevated Myocardial Infarction Predictive Value of Tests ST Elevation Myocardial Infarction Coronary Artery Disease Inflammation Mediators Risk Assessment Severity of Illness Index Epigenesis, Genetic Inflammation DNA Methylation 5-Methylcytosine
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Prognosis modelling of adverse events for post-PCI treated AMI patients based on inflammation and nutrition indexes.

BMC cardiovascular disorders Jan 23, 2025
OBJECTIVE: This study aimed to evaluate the predictive performance of inflammatory and nutritional indices for adverse cardiovascular events (ACE) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI) using...
Nutritional Status Middle Aged Nutrition Assessment Risk Assessment Inflammation Treatment Outcome Decision Trees Predictive Value of Tests Percutaneous Coronary Intervention Myocardial Infarction Inflammation Mediators Biomarkers Female Risk Factors Aged Male Humans Neural Networks, Computer Machine Learning Decision Support Techniques
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Machine Learning Approach for Intraocular Disease Prediction Based on Aqueous Humor Immune Mediator Profiles.

Ophthalmology Jan 21, 2021
PURPOSE: Various immune mediators have crucial roles in the pathogenesis of intraocular diseases. Machine learning can be used to automatically select and weigh various predictors to develop models maximizing predictive power. However, these techniqu...
Retinal Necrosis Syndrome, Acute Humans Machine Learning Interleukins Area Under Curve Cross-Sectional Studies Retinal Detachment Eye Diseases Immunoassay Male Aqueous Humor Flow Cytometry Middle Aged Endophthalmitis Intraocular Lymphoma Female Inflammation Mediators Diagnosis, Computer-Assisted Glaucoma, Open-Angle Reproducibility of Results ROC Curve Aged Aged, 80 and over Adult
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Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure.

Frontiers in immunology Jan 15, 2021
The Pediatric Acute Liver Failure (PALF) study is a multicenter, observational cohort study of infants and children diagnosed with this complex clinical syndrome. Outcomes in PALF reflect interactions among the child's clinical condition, response to...
Male Infant Liver Transplantation Diagnosis, Computer-Assisted Humans Biomarkers Adolescent Machine Learning Inflammation Mediators Time Factors Prognosis Decision Support Techniques Child, Preschool Liver Failure, Acute Female Child Reproducibility of Results Inflammation Risk Factors Age Factors Predictive Value of Tests
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Large-Scale Multi-omic Analysis of COVID-19 Severity.

Cell systems Oct 8, 2020
We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from COVID-19-positive and COVID-19-negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associa...
Male Middle Aged Severity of Illness Index Cohort Studies Sequence Analysis, RNA Gelsolin Neutrophils Principal Component Analysis Inflammation Mediators Machine Learning COVID-19 Female Aged Aged, 80 and over Humans
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ProIn-Fuse: improved and robust prediction of proinflammatory peptides by fusing of multiple feature representations.

Journal of computer-aided molecular design Sep 23, 2020
A proinflammatory peptide (PIP) is a type of signaling molecules that are secreted from immune cells, which contributes to the first line of defense against invading pathogens. Numerous experiments have shown that PIPs play an important role in human...
Computer Simulation Computational Biology Peptide Fragments Inflammation Mediators Humans Machine Learning Algorithms
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Machine Learning to Understand the Immune-Inflammatory Pathways in Fibromyalgia.

International journal of molecular sciences Aug 29, 2019
Fibromyalgia (FM) is a chronic syndrome characterized by widespread musculoskeletal pain, and physical and emotional symptoms. Although its pathophysiology is largely unknown, immune-inflammatory pathways may be involved. We examined serum interleuki...
Surveys and Questionnaires Signal Transduction C-Reactive Protein Pain Inflammation Mediators Multivariate Analysis Fibromyalgia Quality of Life Anxiety Severity of Illness Index Psychiatric Status Rating Scales Depression Humans Machine Learning Cytokines Female Middle Aged
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