Identification of age-specific risk factors for hyperuricemia: a machine learning-driven stratified analysis in health examination cohorts.

Journal: BMC medical informatics and decision making
Published Date:

Abstract

BACKGROUND: Hyperuricemia (HUA) as a global public health challenge, although its overall epidemiological characteristics have been widely reported, its age-specific risk pattern remains controversial. This study aims to reveal the risk factors of HUA in healthy physical examination populations of different age groups and construct a machine learning-driven risk prediction model to achieve precise intervention.

Authors

  • ChuXia Tan
    Health Management Medicine Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Yuan Liu
    Department of General Surgery, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China.
  • Lijun Li
    Department of Orthopedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, PR China; Orthopedics Research Institute of Zhejiang University, Hangzhou, 310000, PR China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou City, Zhejiang Province, PR China. Electronic address: lilijun@zju.edu.cn.
  • Ying Li
    School of Information Engineering, Chang'an University, Xi'an 710010, China.
  • Pingting Yang
    Health Management Medicine Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Yinglong Duan
    Nursing department, the Third Xiangya Hospital, Central South University, Changsha, 410013, China.
  • Xingxing Wang
    Department of Pathology, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai 200032, China.
  • Huiyi Zhang
    Xiangya Nursing School of Central South University, Changsha, 410013, China.
  • Jingying Wang
    Social and Public Administration School, East China University of Science and Technology, Shanghai, China.
  • Honglian Zhang
    State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai, 200050, China.