Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II).

Journal: PloS one
PMID: 39729440

Abstract

BACKGROUND: Exposure of critically ill patients to antibiotics lead to intestinal dysbiosis, which often manifests as antibiotic-associated diarrhoea. Faecal microbiota transplantation restores gut microbiota and may lead to faster resolution of diarrhoea.

Authors

  • Ivana Cibulkova
    Division of Gastroenterology, Department of Internal Medicine, Kralovske Vinohrady University Hospital, Prague, Czech Republic.
  • Veronika Rehorova
    The Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Hana Soukupova
    The Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Petr Waldauf
    The Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Monika Cahova
    Department of Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • Jan Manak
    3rd Department of Internal Medicine-Metabolism and Gerontology, Charles University Teaching Hospital Hradec Kralove, Hradec Kralove, Czech Republic.
  • Martin Matejovic
    1st Department of Internal Medicine, Faculty of Medicine in Pilsen, Pilsen University Hospital, Pilsen, Czech Republic.
  • Frantisek Duska
    The Third Faculty of Medicine, Charles University, Prague, Czech Republic.

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