AIMC Topic: Dysbiosis
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Gut microbiota alterations are linked to COVID-19 severity in North African and European populations.
NPJ biofilms and microbiomes
Jun 13, 2025
Although COVID-19 primarily affects the respiratory system, many patients experience gastrointestinal symptoms, suggesting a role for the gut microbiota in disease pathogenesis. To explore this, we performed shotgun metagenomic sequencing on stool sa...
Machine learning based gut microbiota pattern and response to fiber as a diagnostic tool for chronic inflammatory diseases.
BMC microbiology
Jun 6, 2025
Gut microbiota has been implicated in the pathogenesis of multiple gastrointestinal (GI) and systemic metabolic and inflammatory disorders where disrupted gut microbiota composition and function (dysbiosis) has been found in multiple studies. Thus, h...
Microbiome and fragmentation pattern of blood cell-free DNA and fecal metagenome enhance colorectal cancer micro-dysbiosis and diagnosis analysis: a proof-of-concept study.
mSystems
Apr 29, 2025
Colorectal cancer (CRC) is the third most common cancer, and it can be prevented by performing early screening. As a hallmark of cancer, the human microbiome plays important roles in the occurrence and development of CRC. Recently, the blood microbio...
Gut microbial composition associated with risk of premature aging in women with Yin-deficiency constitution.
Frontiers in cellular and infection microbiology
Jan 3, 2025
BACKGROUND: Yin-deficiency constitution (YinDC) refers to a traditional Chinese medicine concept, characterized by an imbalance state that includes an imbalance in the gut microbiota, resulting from a relative deficiency of Yin fluids within the body...
Allogenic faecal microbiota transplantation for antibiotic-associated diarrhoea in critically ill patients (FEBATRICE)-Study protocol for a multi-centre randomised controlled trial (phase II).
PloS one
Dec 27, 2024
BACKGROUND: Exposure of critically ill patients to antibiotics lead to intestinal dysbiosis, which often manifests as antibiotic-associated diarrhoea. Faecal microbiota transplantation restores gut microbiota and may lead to faster resolution of diar...
Unravelling metabolite-microbiome interactions in inflammatory bowel disease through AI and interaction-based modelling.
Biochimica et biophysica acta. Molecular basis of disease
Dec 9, 2024
Inflammatory Bowel Diseases (IBDs) are chronic inflammatory disorders of the gastrointestinal tract and colon affecting approximately 7 million individuals worldwide. The knowledge of specific pathology and aetiological mechanisms leading to IBD is l...
The potential value of oral microbial signatures for prediction of oral squamous cell carcinoma based on machine learning algorithms.
Head & neck
May 2, 2024
OBJECTIVE: This study aimed to explore the potential predictive value of oral microbial signatures for oral squamous cell carcinoma (OSCC) risk based on machine learning algorithms.
Accurate diagnosis of atopic dermatitis by combining transcriptome and microbiota data with supervised machine learning.
Scientific reports
Jan 7, 2022
Atopic dermatitis (AD) is a common skin disease in childhood whose diagnosis requires expertise in dermatology. Recent studies have indicated that host genes-microbial interactions in the gut contribute to human diseases including AD. We sought to de...
Gut microbiome-mediated epigenetic regulation of brain disorder and application of machine learning for multi-omics data analysis.
Genome
Oct 8, 2020
The gut-brain axis (GBA) is a biochemical link that connects the central nervous system (CNS) and enteric nervous system (ENS). Clinical and experimental evidence suggests gut microbiota as a key regulator of the GBA. Microbes living in the gut not o...
Elevation of serum pyruvate kinase M2 (PKM2) in IBD and its relationship to IBD indices.
Clinical biochemistry
Dec 19, 2017
OBJECTIVES: Endoscopy remains the gold standard to diagnose and evaluate inflammatory bowel disease (IBD) activity. Current biomarkers or their combinations cannot adequately predict IBD risk, diagnosis, progression or relapse, and response to therap...
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