Impact of deep learning model uncertainty on manual corrections to MRI-based auto-segmentation in prostate cancer radiotherapy.

Journal: Journal of applied clinical medical physics
Published Date: Sep 1, 2025

Abstract

BACKGROUND: Deep learning (DL)-based organ segmentation is increasingly used in radiotherapy. While methods exist to generate voxel-wise uncertainty maps from DL-based auto-segmentation models, these maps are rarely presented to clinicians.

Authors

  • Viktor Rogowski
    Radiation Physics, Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Angelica Svalkvist
    Department of Medical Physics and Biomedical Engineering, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Matteo Maspero
    Department of Radiation Oncology, Imaging and Cancer Division, University Medical Center Utrecht, Utrecht, The Netherlands; Computational Imaging Group for MR Diagnostics & Therapy, Center for Image Sciences, University Medical Center Utrecht, Utrecht, The Netherlands.
  • Tomas Janssen
    Department of Radiation Oncology, The Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam, The Netherlands.
  • Federica Carmen Maruccio
    Philips Research, HTC 34, North Brabant, 5656 AE, NL, The Netherlands.
  • Jenny Gorgisyan
    Radiation Physics, Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Jonas Scherman
    Department of Hematology Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Ida Häggström
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States. Electronic address: haeggsti@mskcc.org.
  • Victor Wåhlstrand
    Department of Electrical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
  • Adalsteinn Gunnlaugsson
    Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Martin P Nilsson
    Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Mathieu Moreau
    Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Nándor Vass
    Department of Hematology, Oncology, and Radiation Physics, Skåne University Hospital, Lund, Sweden.
  • Niclas Pettersson
    Department of Medical Radiation Sciences, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Christian Jamtheim Gustafsson
    Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.

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