Potential effects of endocrine-disrupting chemicals on preserved ratio impaired spirometry revealed by five different approaches.

Journal: Ecotoxicology and environmental safety
Published Date: Jul 21, 2025

Abstract

OBJECTIVE: Evidence from prior studies indicates that certain endocrine-disrupting chemicals (EDCs), such as phenols and phthalates, may serve as environmental risk factors for chronic obstructive pulmonary disease (COPD). However, no studies have examined the potential associations between EDCs and preserved ratio impaired spirometry (PRISm), a precursor to COPD.

Authors

  • Chenyuan Deng
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China. Electronic address: dengcy0758@163.com.
  • Yu Jiang
    School of Pharmacy and Food Engineering, Wuyi University, Jiangmen, China.
  • Yuechun Lin
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, Guangdong, China.
  • Hengrui Liang
    China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
  • Wei Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
  • Ying Huang
    Department of Otolaryngology, Head and Neck Surgery, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan, China.
  • Jianxing He
    Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou 510120, China.

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