PDON: Parkinson's disease ontology for representation and modeling of the Parkinson's disease knowledge domain.

Journal: Theoretical biology & medical modelling
Published Date: Sep 22, 2015

Abstract

BACKGROUND: Despite the unprecedented and increasing amount of data, relatively little progress has been made in molecular characterization of mechanisms underlying Parkinson's disease. In the area of Parkinson's research, there is a pressing need to integrate various pieces of information into a meaningful context of presumed disease mechanism(s). Disease ontologies provide a novel means for organizing, integrating, and standardizing the knowledge domains specific to disease in a compact, formalized and computer-readable form and serve as a reference for knowledge exchange or systems modeling of disease mechanism.

Authors

  • Erfan Younesi
    Department of Bionformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany. erfan.younesi@scai.fraunhofer.de.
  • Ashutosh Malhotra
    Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany.
  • Michaela Gündel
    Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany.
  • Phil Scordis
    Informatics group, UCB Pharma, 208 Bath Road, Slough, UK. phil.scordis@ucb.com.
  • Alpha Tom Kodamullil
    Department of Bionformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany. alpha.tom.kodamullil@scai.fraunhofer.de.
  • Matt Page
    Informatics group, UCB Pharma, 208 Bath Road, Slough, UK. matt.page@ucb.com.
  • Bernd Müller
    Department of Bionformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany. bernd.mueller@scai.fraunhofer.de.
  • Stephan Springstubbe
    Department of Bionformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany. stephan.springstubbe@scai.fraunhofer.de.
  • Ullrich Wüllner
    Department of Neurology, University of Bonn, 53105, Bonn, Germany. ullrich.wuellner@ukb.uni-bonn.de.
  • Dieter Scheller
    Pharmacology Parkinson's Disease and Movement Disorders, UCB Pharma S.A., Chemin du Foriest, B-1420, Braine-l'Allued, Belgium. dieter.scheller@ucb.com.
  • Martin Hofmann-Apitius
    Department of Bioinformatics, Fraunhofer Institute for Algorithms and Scientific Computing, 53754, Sankt Augustin, Germany.

Keywords

External Resources

Popular Topics
Recent Journals