Use of machine learning in predicting clinical response to transcranial magnetic stimulation in comorbid posttraumatic stress disorder and major depression: A resting state electroencephalography study.

Journal: Journal of affective disorders
PMID: 30978624

Abstract

BACKGROUND: Repetitive transcranial magnetic stimulation (TMS) is clinically effective for major depressive disorder (MDD) and investigational for other conditions including posttraumatic stress disorder (PTSD). Understanding the mechanisms of TMS action and developing biomarkers predicting response remain important goals. We applied a combination of machine learning and electroencephalography (EEG), testing whether machine learning analysis of EEG coherence would (1) predict clinical outcomes in individuals with comorbid MDD and PTSD, and (2) determine whether an individual had received a TMS course.

Authors

  • Amin Zandvakili
    Butler Hospital, Providence, RI 02906, United States; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, United States; Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI 02908, United States. Electronic address: amin_zandvakili@brown.edu.
  • Noah S Philip
    Butler Hospital, Providence, RI 02906, United States; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, United States; Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI 02908, United States.
  • Stephanie R Jones
    Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI 02908, United States; Department of Neuroscience, Brown University, Providence, RI 02906, United States.
  • Audrey R Tyrka
    Butler Hospital, Providence, RI 02906, United States; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, United States.
  • Benjamin D Greenberg
    Butler Hospital, Providence, RI 02906, United States; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, United States; Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI 02908, United States.
  • Linda L Carpenter
    Butler Hospital, Providence, RI 02906, United States; Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI 02906, United States.

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