Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study.

Journal: The Lancet. Respiratory medicine
Published Date:

Abstract

BACKGROUND: In the appropriate clinical setting, the diagnosis of idiopathic pulmonary fibrosis (IPF) requires a pattern of usual interstitial pneumonia to be present on high-resolution chest CT (HRCT) or surgical lung biopsy. A molecular usual interstitial pneumonia signature can be identified by a machine learning algorithm in less-invasive transbronchial lung biopsy samples. We report prospective findings for the clinical validity and utility of this molecular test.

Authors

  • Ganesh Raghu
    University of Washington Medical Center, Seattle, WA, USA.
  • Kevin R Flaherty
    University of Michigan, Ann Arbor, MI, USA.
  • David J Lederer
    Department of Medicine and Epidemiology, Columbia University, New York, NY, USA.
  • David A Lynch
    National Jewish Health, Denver, CO, USA.
  • Thomas V Colby
    Mayo Clinic, Scottsdale, AZ, USA.
  • Jeffrey L Myers
    University of Michigan, Ann Arbor, MI, USA.
  • Steve D Groshong
    5 Department of Medicine, National Jewish Health, Denver, Colorado.
  • Brandon T Larsen
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Scottsdale, AZ, USA.
  • Jonathan H Chung
    Department of Radiology, University of Chicago Medicine, Chicago, IL, USA.
  • Mark P Steele
    Vanderbilt University, Nashville, TN, USA.
  • Sadia Benzaquen
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH, USA.
  • Karel Calero
    Department of Internal Medicine, University of South Florida, Tampa, FL, USA.
  • Amy H Case
    Division of Pulmonary, Critical Care, and Sleep Medicine, Piedmont Healthcare, Atlanta, GA, USA.
  • Gerard J Criner
    Temple University Hospital, Philadelphia, PA, USA. gerard.criner@tuhs.temple.edu.
  • Steven D Nathan
    Inova Fairfax Hospital, Falls Church, VA, USA.
  • Navdeep S Rai
    Pulmonary, Critical Care and Sleep Medicine, Pulmonary Consultants, PLLC, Tacoma, WA, USA.
  • Murali Ramaswamy
    Pulmonary and Critical Care Medicine, Pulmonlx, Greensboro, NC, USA; Cone Health, Greensboro, NC, USA.
  • Lars Hagmeyer
    Clinic of Pneumology and Allergology, Centre of Sleep Medicine and Respiratory Care, Hospital Bethanien Hospital Solingen, Germany.
  • J Russell Davis
    Department of Cardiothoracic Surgery, Saint Luke's Hospital, Kansas City, MO, USA.
  • Umair A Gauhar
    Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, University of Louisville, Louisville, KY, USA.
  • Daniel G Pankratz
    1 Veracyte, Inc., South San Francisco, California.
  • Yoonha Choi
    Veracyte, South San Francisco, CA, USA.
  • Jing Huang
    Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • P Sean Walsh
  • Hannah Neville
    Veracyte, San Francisco, CA, USA.
  • Lori R Lofaro
    Veracyte, San Francisco, CA, USA.
  • Neil M Barth
    1 Veracyte, Inc., South San Francisco, California.
  • Giulia C Kennedy
  • Kevin K Brown
    National Jewish Health, Denver, CO, USA.
  • Fernando J Martinez
    9 Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical College, New York, New York.