Machine learning for prediction of chemoradiation therapy response in rectal cancer using pre-treatment and mid-radiation multi-parametric MRI.

Journal: Magnetic resonance imaging
Published Date:

Abstract

PURPOSE: To predict the neoadjuvant chemoradiation therapy (CRT) response in patients with locally advanced rectal cancer (LARC) using radiomics and deep learning based on pre-treatment MRI and a mid-radiation follow-up MRI taken 3-4 weeks after the start of CRT.

Authors

  • Liming Shi
    Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  • Yang Zhang
    Innovative Institute of Chinese Medicine and Pharmacy, Academy for Interdiscipline, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • Ke Nie
    Department of Radiation Oncology, Rutgers-Cancer Institute of New Jersey, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, United States.
  • Xiaonan Sun
    Department of Radiation Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: sunxiaonan@zju.edu.cn.
  • Tianye Niu
    Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
  • Ning Yue
    Department of Radiation Oncology, Rutgers-The State University of New Jersey, New Brunswick, NJ, USA.
  • Tiffany Kwong
    Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall, Irvine, CA, 92697-5020.
  • Peter Chang
    Department of Urology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Daniel Chow
    Department of Radiological Sciences, John Tu and Thomas Yuen Center for Functional Onco-Imaging, University of California, 164 Irvine Hall, Irvine, CA, 92697-5020.
  • Jeon-Hor Chen
    Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung 82445, Taiwan and Tu and Yuen Center for Functional Onco-Imaging and Department of Radiological Science, University of California, Irvine, California 92697.
  • Min-Ying Su
    Department of Radiological Sciences, University of California, Irvine, CA 92697, USA.