AIMC Topic: Tumor Burden

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GTV segmentation in MRI guided radiotherapy with promptable foundation models.

Physics in medicine and biology
. Magnetic resonance imaging (MRI) guided radiotherapy requires the delineation of gross tumor volumes (GTV) in daily MRI from MRI-linacs. Specialized models have been developed for this task for certain tumors. This study investigated an alternative...

Deep Learning for Automated Measures of SUV and Molecular Tumor Volume in [Ga]PSMA-11 or [F]DCFPyL, [F]FDG, and [Lu]Lu-PSMA-617 Imaging with Global Threshold Regional Consensus Network.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Metastatic castration-resistant prostate cancer has a high rate of mortality with a limited number of effective treatments after hormone therapy. Radiopharmaceutical therapy with [Lu]Lu-prostate-specific membrane antigen-617 (LuPSMA) is one treatment...

[Ga]Ga-PSMA-11 PET Tumor Volume Predicts Overall Survival of Patients with Metastatic Prostate Cancer Undergoing Taxane-Based Chemotherapy.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Prostate-specific membrane antigen (PSMA) PET has the potential to monitor the response to taxane-based chemotherapy in patients with prostate cancer and shows promise for predicting outcomes and improving response evaluation. This retrospective stud...

Automated contouring of gross tumor volume lymph nodes in lung cancer by deep learning.

BMC cancer
PURPOSE: The precise contouring of gross tumor volume lymph nodes (GTVnd) is an essential step in clinical target volume delineation. This study aims to propose and evaluate a deep learning model for segmenting GTVnd specifically in lung cancer, repr...

External validation of deep learning-derived 18F-FDG PET/CT delta biomarkers for loco-regional control in head and neck cancer.

Acta oncologica (Stockholm, Sweden)
BACKGROUND AND PURPOSE: Delta biomarkers that reflect changes in tumour burden over time can support personalised follow-up in head and neck cancer. However, their clinical use can be limited by the need for manual image segmentation. This study exte...

TG-Mamba: Leveraging text guidance for predicting tumor mutation burden in lung cancer.

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Tumor mutation burden (TMB) is a crucial biomarker for predicting the response of lung cancer patients to immunotherapy. Traditionally, TMB is quantified through whole-exome sequencing (WES), but the high costs and time requirements of WES limit its ...

Interactive 3D segmentation for primary gross tumor volume in oropharyngeal cancer.

Scientific reports
Radiotherapy is the main treatment modality of oropharyngeal cancer (OPC), in which an accurate segmentation of primary gross tumor volume (GTVt) is essential but also challenging due to significant interobserver variability and the time consumed in ...

Size-Specific Predictors for Malignancy Risk in Follicular Thyroid Neoplasms: Machine Learning Analysis.

JMIR cancer
BACKGROUND: Surgeons often face challenges in distinguishing between benign and malignant follicular thyroid neoplasms (FTNs), particularly small tumors, until diagnostic surgery is performed.

The Desmoid Dilemma: Challenges and Opportunities in Assessing Tumor Burden and Therapeutic Response.

Current oncology (Toronto, Ont.)
Desmoid tumors are rare, locally invasive soft-tissue tumors with unpredictable clinical behavior. Imaging plays a crucial role in their diagnosis, measurement of disease burden, and assessment of treatment response. However, desmoid tumors' unique i...

Reirradiation for recurrent glioblastoma: the significance of the residual tumor volume.

Journal of neuro-oncology
PURPOSE: Recurrent glioblastoma has a poor prognosis, and its optimal management remains unclear. Reirradiation (re-RT) is a promising treatment option, but long-term outcomes and optimal patient selection criteria are not well established.