Influence of Coronary Calcium on Diagnostic Performance of Machine Learning CT-FFR: Results From MACHINE Registry.

Journal: JACC. Cardiovascular imaging
Published Date: Mar 1, 2020

Abstract

OBJECTIVES: This study was conducted to investigate the influence of coronary artery calcium (CAC) score on the diagnostic performance of machine-learning-based coronary computed tomography (CT) angiography (cCTA)-derived fractional flow reserve (CT-FFR).

Authors

  • Christian Tesche
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Katharina Otani
    Advanced Therapies Innovation Department, Siemens Healthcare K.K., Tokyo, Japan.
  • Carlo N De Cecco
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Adriaan Coenen
    Department of Cardiology (A.C., M.L.L., J.D., K.N.) a.coenen@erasmusmc.nl.
  • Jakob De Geer
    Department of Radiology and Department of Medical and Health Sciences, Center for Medical Image Science and Visualization, Linköping University, Sweden (J.D.G., A.P.).
  • Mariusz Kruk
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Coronary Disease and Structural Heart Diseases Department, Institute of Cardiology, Warsaw, Poland (M.K., C.K.).
  • Young-Hak Kim
    Asan Medical Center, Seoul, Republic of Korea.
  • Moritz H Albrecht
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina; Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany.
  • Stefan Baumann
    From the Division of Cardiovascular Imaging, Department of Radiology and Radiological Science (C.T., C.N.D.C., S.B., M.R., T.W.M., T.M.D., R.R.B., U.J.S.), and Division of Cardiology, Department of Medicine (R.R.B., D.H.S., U.J.S.), Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260; Department of Computed Tomography-Research & Development, Siemens Healthcare GmbH, Forchheim, Germany (K.L.G., C.C., C.S., M.S.); Department of Corporate Technology, Siemens SRL, Brasov, Romania (L.M.I.); and Department of Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ (S.R., P.S.).
  • Matthias Renker
    From the Division of Cardiovascular Imaging, Department of Radiology and Radiological Science (C.T., C.N.D.C., S.B., M.R., T.W.M., T.M.D., R.R.B., U.J.S.), and Division of Cardiology, Department of Medicine (R.R.B., D.H.S., U.J.S.), Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260; Department of Computed Tomography-Research & Development, Siemens Healthcare GmbH, Forchheim, Germany (K.L.G., C.C., C.S., M.S.); Department of Corporate Technology, Siemens SRL, Brasov, Romania (L.M.I.); and Department of Medical Imaging Technologies, Siemens Healthcare, Princeton, NJ (S.R., P.S.).
  • Richard R Bayer
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Taylor M Duguay
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina.
  • Sheldon E Litwin
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
  • Akos Varga-Szemes
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).
  • Daniel H Steinberg
    Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.
  • Dong Hyun Yang
    Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  • Cezary Kepka
    Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Coronary Disease and Structural Heart Diseases Department, Institute of Cardiology, Warsaw, Poland (M.K., C.K.).
  • Anders Persson
    Department of Radiology and Department of Medical and Health Sciences, Center for Medical Image Science and Visualization, Linköping University, Sweden (J.D.G., A.P.).
  • Koen Nieman
    Department of Cardiology (A.C., M.L.L., J.D., K.N.).
  • U Joseph Schoepf
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, Ashley River Tower, 25 Courtenay Dr, Charleston, SC 29425-2260 (S.S.M., D.M., M.v.A., C.N.D.C., R.R.B., C.T., A.V.S., A.M.F., B.E.J., L.P.G., U.J.S.); Department of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Frankfurt, Germany (S.S.M., T.J.V.); Stanford University School of Medicine, Department of Radiology, Stanford, Calif (D.M.); Division of Cardiothoracic Imaging, Nuclear Medicine and Molecular Imaging, Department of Radiology and Imaging Sciences, Emory University, Atlanta, Ga (C.N.D.C.); Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC (R.R.B.); Department of Cardiology and Intensive Care Medicine, Heart Center Munich-Bogenhausen, Munich, Germany (C.T.); Department of Cardiology, Munich University Clinic, Ludwig-Maximilians-University, Munich, Germany (C.T.); Siemens Medical Solutions USA, Malvern, Pa (P.S.); and Department of Emergency Medicine, Medical University of South Carolina, Charleston, SC (A.J.M.).

Keywords

External Resources

Popular Topics
Recent Journals