A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine.

Journal: BMC genomics
PMID: 31722674

Abstract

BACKGROUND: Recent studies have shown that long non-coding RNAs (lncRNAs) play a crucial role in the induction of cancer through epigenetic regulation, transcriptional regulation, post-transcriptional regulation and other aspects, thus participating in various biological processes such as cell proliferation, differentiation and apoptosis. As a new nova of anti-tumor therapy, immunotherapy has been shown to be effective in many tumors of which PD-1/PD-L1 monoclonal antibodies has been proofed to increase overall survival rate in advanced gastric cancer (GC). Microsatellite instability (MSI) was known as a biomarker of response to PD-1/PD-L1 monoclonal antibodies therapy. The aim of this study was to identify lncRNAs signatures able to classify MSI status and create a predictive model associated with MSI for GC patients.

Authors

  • Tao Chen
    School of Automation, Northwestern Polytechnical University, Xi'an, 710072, Shaanxi, China.
  • Cangui Zhang
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, No.1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
  • Yingqiao Liu
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangdong Provincial Engineering Technology Research Center of Minimally Invasive Surgery, No.1838, North Guangzhou Avenue, Guangzhou, 510515, Guangdong Province, China.
  • Yuyun Zhao
    School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
  • Dingyi Lin
    School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
  • Yanfeng Hu
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Jiang Yu
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Guoxin Li
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China. gzliguoxin@163.com caishirong@yeah.net ehbhltj@hotmail.com keekee77@126.com.

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