Utilizing Machine Learning for Pre- and Postoperative Assessment of Patients Undergoing Resection for BCLC-0, A and B Hepatocellular Carcinoma: Implications for Resection Beyond the BCLC Guidelines.

Journal: Annals of surgical oncology
Published Date: Nov 6, 2019

Abstract

BACKGROUND: There is an ongoing debate about expanding the resection criteria for hepatocellular carcinoma (HCC) beyond the Barcelona Clinic Liver Cancer (BCLC) guidelines. We sought to determine the factors that held the most prognostic weight in the pre- and postoperative setting for each BCLC stage by applying a machine learning method.

Authors

  • Diamantis I Tsilimigras
    Department of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Rittal Mehta
    Department of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
  • Dimitrios Moris
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Kota Sahara
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Fabio Bagante
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Anghela Z Paredes
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Ayesha Farooq
    Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  • Francesca Ratti
    Division of Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Milano, Italy. Electronic address: ratti.francesca@hsr.it.
  • Hugo P Marques
    Department of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
  • Silvia Silva
    Department of Surgery, Curry Cabral Hospital, Lisbon, Portugal.
  • Olivier Soubrane
    Department of HPB Surgery and Liver Transplantation, Hôpital Beaujon, AP-HP, Clichy, France.
  • Vincent Lam
    Department of Surgery, Westmead Hospital, Sydney, NSW, Australia.
  • George A Poultsides
    Department of Surgery, Stanford University, Stanford, CA, USA.
  • Irinel Popescu
    Department of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
  • Razvan Grigorie
    Department of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
  • Sorin Alexandrescu
    Department of Surgery, Fundeni Clinical Institute, Bucharest, Romania.
  • Guillaume Martel
    Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
  • Aklile Workneh
    Department of Surgery, University of Ottawa, Ottawa, ON, Canada.
  • Alfredo Guglielmi
    Department of Surgery, University of Verona, Verona, Italy.
  • Tom Hugh
    Department of Surgery, The University of Sydney, School of Medicine, Sydney, NSW, Australia.
  • Luca Aldrighetti
    Division of Hepatobiliary Surgery, IRCCS San Raffaele Hospital, Milano, Italy.
  • Itaru Endo
    Department of Gastroenterological Surgery Yokohama City University Graduate School of Medicine Yokohama Japan.
  • Timothy M Pawlik
    Department of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH.

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