Identifying Phenogroups in patients with subclinical diastolic dysfunction using unsupervised statistical learning.

Journal: BMC cardiovascular disorders
PMID:

Abstract

BACKGROUND: Subclinical diastolic dysfunction is a precursor for developing heart failure with preserved ejection fraction (HFpEF); yet not all patients progress to HFpEF. Our objective was to evaluate clinical and echocardiographic variables to identify patients who develop HFpEF.

Authors

  • Yvonne E Kaptein
    Aurora Cardiovascular Services, Aurora St Luke's Medical Center, Milwaukee, WI, USA. yvonne.kaptein@gmail.com.
  • Ilya Karagodin
    Department of Medicine, University of Chicago, Chicago, USA.
  • Hongquan Zuo
    Electrical Engineering and Computer Science, University of Wisconsin-Milwaukee, Milwaukee, USA.
  • Yu Lu
    Faw-volkswagen Automative Co., Changchun, China.
  • Jun Zhang
    First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
  • John S Kaptein
    University of Southern California, Los Angeles, USA.
  • Jennifer L Strande
    Department of Medicine, Medical College of Wisconsin, Milwaukee, USA.