Temporal Lobe Epilepsy Surgical Outcomes Can Be Inferred Based on Structural Connectome Hubs: A Machine Learning Study.

Journal: Annals of neurology
PMID: 32827235

Abstract

OBJECTIVE: Medial temporal lobe epilepsy (TLE) is the most common form of medication-resistant focal epilepsy in adults. Despite removal of medial temporal structures, more than one-third of patients continue to have disabling seizures postoperatively. Seizure refractoriness implies that extramedial regions are capable of influencing the brain network and generating seizures. We tested whether abnormalities of structural network integration could be associated with surgical outcomes.

Authors

  • Ezequiel Gleichgerrcht
    Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.
  • Simon S Keller
    Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool L69 7BE, UK.
  • Daniel L Drane
    Department of Neurology, Emory University, Atlanta, GA 30322, USA.
  • Brent C Munsell
    Department of Computer Science, College of Charleston, Charleston, SC, USA. Electronic address: munsellb@cofc.edu.
  • Kathryn A Davis
    Penn Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104; Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
  • Erik Kaestner
    Neurosciences Program, University of California San Diego, La Jolla, CA, 92096, USA.
  • Bernd Weber
    Institute of Experimental Epileptology and Cognition Research, University of Bonn, Bonn 53113, Germany.
  • Samantha Krantz
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
  • William A Vandergrift
    Department of Neurosurgery, Medical University of South Carolina, Charleston, South Carolina.
  • Jonathan C Edwards
    Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.
  • Carrie R McDonald
    Department of Psychiatry, University of California San Diego School of Medicine, La Jolla, CA.
  • Ruben Kuzniecky
    Department of Neurology, Hofstra University/Northwell, New York, NY 10075, USA.
  • Leonardo Bonilha
    Department of Neurology, Medical University of South Carolina, Charleston, SC 29425, USA.

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