The Immune Subtypes and Landscape of Gastric Cancer and to Predict Based on the Whole-Slide Images Using Deep Learning.

Journal: Frontiers in immunology
PMID:

Abstract

BACKGROUND: Gastric cancer (GC) is a highly heterogeneous tumor with different responses to immunotherapy. Identifying immune subtypes and landscape of GC could improve immunotherapeutic strategies.

Authors

  • Yan Chen
    Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Zepang Sun
    Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  • Wanlan Chen
    Department of Cardiology, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Changyan Liu
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Ruoyang Chai
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Jingjing Ding
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Wen Liu
    Department of Dermatology, Air Force General Hospital, PLA Beijing 100142, China.
  • Xianzhen Feng
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Jun Zhou
    Department of Clinical Research Center, Dazhou Central Hospital, Dazhou 635000, China.
  • Xiaoyi Shen
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
  • Shan Huang
    Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, 300211 Tianjin, China.
  • Zhongqing Xu
    Department of General Practice, Tongren Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.