Sex Differences of Brain Functional Topography Revealed in Normal Aging and Alzheimer's Disease Cohort.

Journal: Journal of Alzheimer's disease : JAD
Published Date: Jan 1, 2021

Abstract

We applied graph theory analysis on resting-state functional magnetic resonance imaging data to evaluate sex differences of brain functional topography in normal controls (NCs), early mild cognitive impairment (eMCI), and AD patients. These metrics were correlated with RAVLT verbal learning and memory scores. The results show NCs have better functional connectivity (FC) metrics than eMCI and AD, and NC women show worse FC metrics compared to men, despite performing better on the RAVLT. FC differences between men and women diminished in eMCI and disappeared in AD. Within women, better FC metrics relate to better RAVLT learning in NCs and eMCI groups.

Authors

  • Filippo Cieri
    Department of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.
  • Zhengshi Yang
    Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA.
  • Dietmar Cordes
    Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, 89106, USA; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, 80309, USA. Electronic address: cordesd@ccf.org.
  • Jessica Z K Caldwell
    Department of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV, USA.

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