Machine learning-based differentiation between multiple sclerosis and glioma WHO II°-IV° using O-(2-[18F] fluoroethyl)-L-tyrosine positron emission tomography.

Journal: Journal of neuro-oncology
Published Date:

Abstract

INTRODUCTION: This study aimed to test the diagnostic significance of FET-PET imaging combined with machine learning for the differentiation between multiple sclerosis (MS) and glioma II°-IV°.

Authors

  • Sied Kebir
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.
  • Laurèl Rauschenbach
    DKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ), German Cancer Consortium (DKTK), Partner Site University Hospital Essen, Essen, Germany.
  • Manuel Weber
  • Lazaros Lazaridis
  • Teresa Schmidt
  • Kathy Keyvani
    Neurosurgery.
  • Niklas Schäfer
    Division of Clinical Neurooncology, Department of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany.
  • Asma Milia
    Department of Pulmonology and Cardiology, Petrus Hospital Academic Teaching, Wuppertal, Germany.
  • Lale Umutlu
    Institute of Diagnostic and Interventional Radiology and Neuroradiology, Departments of.
  • Daniela Pierscianek
  • Martin Stuschke
    Radiotherapy, and.
  • Michael Forsting
    Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstraße 55, 45147, Essen, Germany.
  • Ulrich Sure
  • Christoph Kleinschnitz
    Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
  • Gerald Antoch
    University Dusseldorf, Medical Faculty, Department of Diagnostic and Interventional Radiology, Germany.
  • Patrick M Colletti
    From the Department of Radiology, Keck School of Medicine of USC, 1500 San Pablo St, Los Angeles, CA 90033.
  • Domenico Rubello
    Nuclear Medicine Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address: domenico.rubello@libero.it.
  • Ken Herrmann
    Department of Nuclear Medicine, Universitätsklinikum Essen, Essen, Germany.
  • Ulrich Herrlinger
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.
  • Björn Scheffler
    Stem Cell Pathologies Group, Institute of Reconstructive Neurobiology, University of Bonn Medical Center, Germany.
  • Ralph A Bundschuh
    Department of Nuclear Medicine, University of Bonn Medical Center, Germany.
  • Martin Glas
    Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Germany.