Neurovascular multiparametric MRI defines epileptogenic and seizure propagation regions in experimental mesiotemporal lobe epilepsy.

Journal: Epilepsia
Published Date: May 1, 2021

Abstract

OBJECTIVE: Improving the identification of the epileptogenic zone and associated seizure-spreading regions represents a significant challenge. Innovative brain-imaging modalities tracking neurovascular dynamics during seizures may provide new disease biomarkers.

Authors

  • Fabien Boux
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.
  • Florence Forbes
    Inria, CNRS, G-INP, University of Grenoble Alpes, Grenoble, France.
  • Nora Collomb
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.
  • Emma Zub
    Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (University of Montpellier, UMR 5203 CNRS, U 1191 INSERM), Montpellier, France.
  • Lucile Mazière
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.
  • Fréderic de Bock
    Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (University of Montpellier, UMR 5203 CNRS, U 1191 INSERM), Montpellier, France.
  • Marine Blaquiere
    Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (University of Montpellier, UMR 5203 CNRS, U 1191 INSERM), Montpellier, France.
  • Vasile Stupar
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.
  • Antoine Depaulis
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.
  • Nicola Marchi
    Cerebrovascular and Glia Research, Department of Neuroscience, Institute of Functional Genomics (University of Montpellier, UMR 5203 CNRS, U 1191 INSERM), Montpellier, France.
  • Emmanuel L Barbier
    Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Inserm, U1216, Grenoble 38000, France.

Keywords

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