A Pilot Study on Automatic Three-Dimensional Quantification of Barrett's Esophagus for Risk Stratification and Therapy Monitoring.

Journal: Gastroenterology
Published Date: Sep 1, 2021

Abstract

BACKGROUND & AIMS: Barrett's epithelium measurement using widely accepted Prague C&M classification is highly operator dependent. We propose a novel methodology for measuring this risk score automatically. The method also enables quantification of the area of Barrett's epithelium (BEA) and islands, which was not possible before. Furthermore, it allows 3-dimensional (3D) reconstruction of the esophageal surface, enabling interactive 3D visualization. We aimed to assess the accuracy of the proposed artificial intelligence system on both phantom and endoscopic patient data.

Authors

  • Sharib Ali
    Institute of Biomedical Engineering, Big Data Institute, Department of Engineering Science, University of Oxford, Oxford, UK. sharib.ali@eng.ox.ac.uk.
  • Adam Bailey
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Stephen Ash
    Ludwig Institute for Cancer Research, University of Oxford, Oxford, United Kingdom.
  • Maryam Haghighat
    Institute of Biomedical Engineering (IBME), Department of Engineering Science, University of Oxford, Old Road Campus Research Building Oxford, Oxford, UK.
  • Simon J Leedham
    Gastrointestinal Stem-cell Biology Laboratory, Oxford Centre for Cancer Gene Research, Wellcome Trust Centre for Human Genetics, Oxford, UK.
  • Xin Lu
    CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • James E East
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.
  • Jens Rittscher
    Department of Engineering Science, University of Oxford, Oxford, United Kingdom.
  • Barbara Braden
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Div., John Radcliffe Hospital, University of Oxford, Oxford, UK.

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