A 3D deep learning model to predict the diagnosis of dementia with Lewy bodies, Alzheimer's disease, and mild cognitive impairment using brain 18F-FDG PET.

Journal: European journal of nuclear medicine and molecular imaging
PMID:

Abstract

PURPOSE: The purpose of this study is to develop and validate a 3D deep learning model that predicts the final clinical diagnosis of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), mild cognitive impairment due to Alzheimer's disease (MCI-AD), and cognitively normal (CN) using fluorine 18 fluorodeoxyglucose PET (18F-FDG PET) and compare model's performance to that of multiple expert nuclear medicine physicians' readers.

Authors

  • Kobra Etminani
    Department of Medical Informatics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: EtminaniK@mums.ac.ir.
  • Amira Soliman
    Center for Applied Intelligent Systems Research (CAISR), Halmstad University, Halmstad, Sweden.
  • Anette Davidsson
    Department of Clinical Physiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
  • Jose R Chang
    Center for Applied Intelligent Systems Research (CAISR), Halmstad University, Halmstad, Sweden.
  • Begoña Martínez-Sanchis
    Department of Nuclear Medicine, Medical Imaging Area, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Stefan Byttner
    Center for Applied Intelligent Systems Research (CAISR), Halmstad University, Halmstad, Sweden.
  • Valle Camacho
    Servicio de Medicina Nuclear, Hospital de La Santa Creu I Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Matteo Bauckneht
    Nuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Roxana Stegeran
    Department of Diagnostic Radiology, Linköping University Hospital, Linköping, Sweden.
  • Marcus Ressner
    Department of Medical Physics, Linköping University Hospital, Linköping, Sweden.
  • Marc Agudelo-Cifuentes
    Department of Nuclear Medicine, Medical Imaging Area, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
  • Andrea Chincarini
    Istituto Nazionale di Fisica Nucleare, Sezione di Genova, Genova, Italy.
  • Matthias Brendel
    Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.
  • Axel Rominger
  • Rose Bruffaerts
    Laboratory for Cognitive Neurology, Department of Neurosciences, KU Leuven, Herestraat 49, 3000, Leuven, Belgium. rose.bruffaerts@kuleuven.be.
  • Rik Vandenberghe
    Department of Neurology, University Hospitals Leuven, Leuven, Belgium.
  • Milica G Kramberger
    Department of Neurology, University Medical Centre Ljubljana, Medical faculty, University of Ljubljana, Slovenia.
  • Maja Trost
    Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
  • Nicolas Nicastro
    Department of Psychiatry, University of Cambridge, Hills Road, Cambridge, CB2 0SP, UK. nn311@medschl.cam.ac.uk.
  • Giovanni B Frisoni
    LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine), IRCCS Centro "S. Giovanni di Dio-F.B.F.", Brescia, Italy; Memory Clinic and LANVIE - Laboratory of Neuroimaging of Aging, University Hospitals and University of Geneva, Geneva, Switzerland.
  • Afina W Lemstra
    Department of Neurology, Alzheimer Center, Amsterdam, The Netherlands.
  • Bart N M van Berckel
    Department of Radiology & Nuclear Medicine, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands.
  • Andrea Pilotto
    Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Alessandro Padovani
    Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Silvia Morbelli
    IRCCS AOU San Martino - IST, Largo R. Benzi 10, 16132 Genoa, Italy.
  • Dag Aarsland
    Centre for Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Flavio Nobili
    Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy.
  • Valentina Garibotto
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospitals, Geneva, Switzerland.
  • Miguel Ochoa-Figueroa
    Department of Clinical Physiology, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.