MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data.

Journal: Briefings in bioinformatics
PMID: 33461213

Abstract

MOTIVATION: Microsatellite instability (MSI) is a promising biomarker for cancer prognosis and chemosensitivity. Techniques are rapidly evolving for the detection of MSI from tumor-normal paired or tumor-only sequencing data. However, tumor tissues are often insufficient, unavailable, or otherwise difficult to procure. Increasing clinical evidence indicates the enormous potential of plasma circulating cell-free DNA (cfNDA) technology as a noninvasive MSI detection approach.

Authors

  • Xinyin Han
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
  • Shuying Zhang
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
  • Daniel Cui Zhou
    McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Dongliang Wang
    ChosenMed Technology (Beijing) Co., Ltd., Beijing 100176, China.
  • Xiaoyu He
    School of Automation, Central South University, Changsha 410083, China.
  • Danyang Yuan
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
  • Ruilin Li
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
  • Jiayin He
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.
  • Xiaohong Duan
    ChosenMed Technology (Beijing) Co., Ltd., Beijing 100176, China.
  • Michael C Wendl
    McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO 63108, USA.
  • Li Ding
    College of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410014, China.
  • Beifang Niu
    Computer Network Information Center, Chinese Academy of Sciences, Beijing 100190, China.

Keywords

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