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Microsatellite Repeats

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MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data.

Briefings in bioinformatics
MOTIVATION: Microsatellite instability (MSI) is a promising biomarker for cancer prognosis and chemosensitivity. Techniques are rapidly evolving for the detection of MSI from tumor-normal paired or tumor-only sequencing data. However, tumor tissues a...

Comparative analysis of high- and low-level deep learning approaches in microsatellite instability prediction.

Scientific reports
Deep learning-based approaches in histopathology can be largely divided into two categories: a high-level approach using an end-to-end model and a low-level approach using feature extractors. Although the advantages and disadvantages of both approach...

Deep learning image analysis quantifies tumor heterogeneity and identifies microsatellite instability in colon cancer.

Journal of surgical oncology
BACKGROUND AND OBJECTIVES: Deep learning utilizing convolutional neural networks (CNNs) applied to hematoxylin & eosin (H&E)-stained slides numerically encodes histomorphological tumor features. Tumor heterogeneity is an emerging biomarker in colon c...

Microsatellite Uncertainty Control Using Deterministic Artificial Intelligence.

Sensors (Basel, Switzerland)
This manuscript explores the applications of deterministic artificial intelligence (DAI) in a space environment in response to unknown sensor noise and sudden changes in craft physical parameters. The current state of the art literature has proposed ...

DeltaMSI: artificial intelligence-based modeling of microsatellite instability scoring on next-generation sequencing data.

BMC bioinformatics
BACKGROUND: DNA mismatch repair deficiency (dMMR) testing is crucial for detection of microsatellite unstable (MSI) tumors. MSI is detected by aberrant indel length distributions of microsatellite markers, either by visual inspection of PCR-fragment ...

Deep learning-based methods for classification of microsatellite instability in endometrial cancer from HE-stained pathological images.

Journal of cancer research and clinical oncology
BACKGROUND: Microsatellite instability (MSI) is one of the essential tumor biomarkers for cancer treatment and prognosis. The presence of more significant PD-L1 expression on the surface of tumor cells in endometrial cancer with MSI suggests that MSI...

An initial exploration of machine learning for establishing associations between genetic markers and THC levels in Cannabis sativa samples.

Forensic science international. Genetics
Cannabis sativa, a globally commercialized plant used for medicinal, food, fiber production, and recreation, necessitates effective identification to distinguish legal and illegal varieties in forensic contexts. This research utilizes multivariate st...

XGBoost as a reliable machine learning tool for predicting ancestry using autosomal STR profiles - Proof of method.

Forensic science international. Genetics
The aim of this study was to test the validity of a predictive model of ancestry affiliation based on Short Tandem Repeat (STR) profiles. Frequencies of 29 genetic markers from the Promega website for four distinct population groups (African American...

A machine learning approach for estimating Eastern Asian origins from massive screening of Y chromosomal short tandem repeats polymorphisms.

International journal of legal medicine
Inferring the ancestral origin of DNA evidence recovered from crime scenes is crucial in forensic investigations, especially in the absence of a direct suspect match. Ancestry informative markers (AIMs) have been widely researched and commercially de...