Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices: INfusor LV (Baxter) and Accufuser (Woo Young Medical): a study compliant with the NHS Yellow Cover Document (YCD) requirements.

Journal: European journal of hospital pharmacy : science and practice
PMID: 32153771

Abstract

OBJECTIVES: To investigate the effect of pH and buffers on the degradation rate of flucloxacillin and to determine if flucloxacillin can be stabilised using a buffered diluent for up to 14 days when stored at 2°C-8°C including a 24-hour infusion period at 32°C in two elastomeric devices (Accufuser and INfusor LV) filled to 240 mL. Testing as per the NHS Pharmaceutical Quality Assurance Committee Yellow Cover Document (YCD) requirements.

Authors

  • Michael Charles Allwood
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Donata Stonkute
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Andrew Wallace
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Alan-Shaun Wilkinson
    Biopharma Stability Testing Laboratory Ltd, Nottingham, UK.
  • Tim Hills
    Pharmacy Department and OPAT Service, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Conor Jamieson
    Pharmacy Department, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.

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