AIMC Topic: Drug Storage
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Stability of Jurkat cells during short-term liquid storage analyzed by flow imaging microscopy.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Mar 26, 2025
The viability of cell-based medicinal products (CBMPs) is a critical quality attribute and must be assessed throughout the product lifecycle to contribute to a safe and potent drug product. In this study, we investigated the impact of short-term liqu...
Particle formation in response to different protein formulations and containers: Insights from machine learning analysis of particle images.
Journal of pharmaceutical sciences
Oct 9, 2024
Subvisible particle count is a biotherapeutics stability indicator widely used by pharmaceutical industries. A variety of stresses that biotherapeutics are exposed to during development can impact particle morphology. By classifying particle morpholo...
Application of machine learning to predict monomer retention of therapeutic proteins after long term storage.
International journal of pharmaceutics
Jan 15, 2020
An important aspect of initial developability assessments as well formulation development and selection of therapeutic proteins is the evaluation of data obtained under accelerated stress condition, i.e. at elevated temperatures. We propose the appli...
Assessment of the stability of citrate-buffered flucloxacillin for injection when stored in two commercially available ambulatory elastomeric devices: INfusor LV (Baxter) and Accufuser (Woo Young Medical): a study compliant with the NHS Yellow Cover Document (YCD) requirements.
European journal of hospital pharmacy : science and practice
Sep 18, 2018
OBJECTIVES: To investigate the effect of pH and buffers on the degradation rate of flucloxacillin and to determine if flucloxacillin can be stabilised using a buffered diluent for up to 14 days when stored at 2°C-8°C including a 24-hour infusion peri...
Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags.
European journal of hospital pharmacy : science and practice
Jul 7, 2018
INTRODUCTION: According to the manufacturers, the diluted solution of etoposide should not exceed 0.4 mg/mL because precipitation may occur. For high doses or for patients requiring fluid restrictions, etoposide phosphate may be an option but shortag...
Preparation, Characterization, and Antitumor Activities of Miriplatin-Loaded Liposomes.
Journal of pharmaceutical sciences
Dec 22, 2015
Because of the insolubility of miriplatin in water, miriplatin and lipiodol suspension is the sole formulation of miriplatin approved in Japan to treat hepatocellular carcinoma by transcatheter arterial chemoembolization. Until now, there have been n...
Stability and compatibility of methotrexate and dexamethasone in 0.9% sodium chloride for intrathecal injection.
Pakistan journal of pharmaceutical sciences
Nov 1, 2020
The stability of a mixture of methotrexate and dexamethasone sodium phosphate in 0.9% sodium chloride for intrathecal (IT) injection was assessed. To simulate the clinically used concentrations of the admixtures, 2mL of 0.9% sodium chloride was added...
Association rule mining for the ordered placement of traditional Chinese medicine containers: An experimental study.
Medicine
May 1, 2020
In traditional Chinese medicine (TCM) clinics, the pharmacists responsible for dispensing the herbal medicine usually find the desired ingredients based on positions of the shelves (racks; frames; stands). Generally, these containers are arranged in ...
Caspofungin infusion solutions (50 mg/100 mL): chemical stability and antifungal activity against Candida spp.
Die Pharmazie
Apr 1, 2017
BACKGROUND: Ready to use caspofungin infusion bags are centrally prepared in the Hospital Pharmacy, University Hospital of Heidelberg, for economic reasons and possibly occurring problems with drug shortages. The aim of this study was a quality contr...
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