Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.

Journal: Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
PMID: 30851776

Abstract

OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR).

Authors

  • Ali Küçüködük
    Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Fatma Helvacioglu
    Department of Histology and Embryology, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Nihan Haberal
    Department of Pathology, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Attila Dagdeviren
    Department of Histology and Embryology, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Didem Bacanli
    Breeding Center, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Gursel Yilmaz
    Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey.
  • Imren Akkoyun
    Department of Ophthalmology, Faculty of Medicine, Baskent University, Ankara, Turkey. Electronic address: retina95akk@yahoo.de.

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