AIMC Topic: Animals, Newborn
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Infant rat ultrasonic vocalizations in the neurodevelopmental model of schizophrenia.
Scientific reports
Jul 28, 2025
Schizophrenia is characterized by early brain developmental abnormalities resulting in, among others, compromised communication. Rodent models, such as prenatal exposure to methylazoxymethanol acetate (MAM), help investigate schizophrenia-related def...
Early transcriptional responses reveal cell type-specific vulnerability and neuroprotective mechanisms in the neonatal ischemic hippocampus.
Acta neuropathologica communications
Jul 5, 2025
Neonatal hypoxic-ischemic (H-I) brain injury, a leading cause of neurodevelopmental disabilities, severely affects the metabolically active and neurogenic hippocampus. To investigate its acute effects and identify drug targets for early therapeutic w...
S-ketamine exposure in early postnatal period induces social deficit mediated by excessive microglial synaptic pruning.
Molecular psychiatry
Mar 11, 2025
The impact of general anesthetics on neurodevelopment is highly controversial in terms of clinical and preclinical studies. Evidence mounted in recent years indicated development of social cognitions was more susceptible to general anesthesia in earl...
Parallel development of object recognition in newborn chicks and deep neural networks.
PLoS computational biology
Dec 2, 2024
How do newborns learn to see? We propose that visual systems are space-time fitters, meaning visual development can be understood as a blind fitting process (akin to evolution) in which visual systems gradually adapt to the spatiotemporal data distri...
Neonatal brain inflammation enhances methamphetamine-induced reinstated behavioral sensitization in adult rats analyzed with explainable machine learning.
Neurochemistry international
Apr 17, 2024
Neonatal brain inflammation produced by intraperitoneal (i.p.) injection of lipopolysaccharide (LPS) results in long-lasting brain dopaminergic injury and motor disturbances in adult rats. The goal of the present work is to investigate the effect of ...
Automated procedure to assess pup retrieval in laboratory mice.
Scientific reports
Jan 31, 2022
All mammalian mothers form some sort of caring bond with their infants that is crucial to the development of their offspring. The Pup Retrieval Test (PRT) is the leading procedure to assess pup-directed maternal care in laboratory rodents, used in a ...
Machine learning-based data analytic approaches for evaluating post-natal mouse respiratory physiological evolution.
Respiratory physiology & neurobiology
Sep 30, 2020
Respiratory parameters change during post-natal development, but the nature of their changes have not been well-described. The advent of commercially available plethysmographic instruments provided improved repeatability of measurements and standardi...
Comparing regression, naive Bayes, and random forest methods in the prediction of individual survival to second lactation in Holstein cattle.
Journal of dairy science
Aug 22, 2019
In this study, we compared multiple logistic regression, a linear method, to naive Bayes and random forest, 2 nonlinear machine-learning methods. We used all 3 methods to predict individual survival to second lactation in dairy heifers. The data set ...
A supervised machine learning approach to characterize spinal network function.
Journal of neurophysiology
Apr 3, 2019
Spontaneous activity is a common feature of immature neuronal networks throughout the central nervous system and plays an important role in network development and consolidation. In postnatal rodents, spontaneous activity in the spinal cord exhibits ...
Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
Apr 11, 2018
OBJECTIVE: To evaluate the impact of intravitreal (IV) and intraperitoneal (IP) astaxanthin (AST) injections on neovascular development (ND), retinal morphology, and apoptotic activity in a C57BL/6J mouse model with hyperoxia-induced retinopathy (HIR...
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