A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Journal: Current pharmaceutical biotechnology

PMID: 29484985

Abstract

BACKGROUND: Alzheimer's disease (AD) is one of most serious threats to human beings, however, the treatment is hindered by blood-brain barrier and poor intra-brain cell selectivity.

Authors

Chi Zhang

Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Zhichun Gu

Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Long Shen

Department of Cardiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Xianyan Liu

Department of Pharmacy, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
Houwen Lin

Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, School of Medicine Shanghai Jiao Tong University Shanghai China.

Keywords

Alzheimer Disease Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases Blood-Brain Barrier Drug Carriers Drug Delivery Systems Gene Knockdown Techniques Humans Mice, Nude Molecular Targeted Therapy Nanoparticles Neurons PC12 Cells Permeability Rats RNA, Small Interfering

External Resources

View on PubMed Access via DOI PubMed (29484985)

A Dual Targeting Drug Delivery System for Penetrating Blood-Brain Barrier and Selectively Delivering siRNA to Neurons for Alzheimer's Disease Treatment.

Abstract

Authors

Keywords

External Resources

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