Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Journal: Drug design, development and therapy

PMID: 29317799

Abstract

OBJECTIVES: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation in ROM, and collagen pathways were identified as differentially expressed over the development of a contracture. Collagenases purified from are currently prescribed to treat Dupuytren's and Peyronie's contractures due to their ability to degrade collagen. The potential application of collagenases to target collagen in the posterior capsule was tested in this model.

Authors

Kayleigh Wong

Bone and Joint Research Laboratory, The Ottawa Hospital Rehabilitation Centre, Ottawa, Ontario.
Guy Trudel

Department of Medicine, Bone and Joint Research Laboratory, The Ottawa Hospital Rehabilitation Centre, Ottawa, Ontario.
Odette Laneuville

Department of Biology, Faculty of Science, University of Ottawa, Ottawa, Ontario, Canada.

Keywords

Animals Biomechanical Phenomena Collagen Type I Collagen Type III Collagenases Contracture Disease Models, Animal Hindlimb Suspension Injections, Intra-Articular Joint Capsule Joints Male Proteolysis Range of Motion, Articular Rats, Sprague-Dawley Recovery of Function Time Factors

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View on PubMed Access via DOI PubMed (29317799)

Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Abstract

Authors

Keywords

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