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Intra-articular collagenase injection increases range of motion in a rat knee flexion contracture model.

Drug design, development and therapy
OBJECTIVES: A knee joint contracture, a loss in passive range of motion (ROM), can be caused by prolonged immobility. In a rat knee immobilization flexion contracture model, the posterior capsule was shown to contribute to an irreversible limitation ...

A Comprehensive Analysis of MicroRNAs in Human Osteoporosis.

Frontiers in endocrinology
MicroRNAs (miRNAs) are single-stranded RNA molecules that control gene expression in various processes, such as cancers, Alzheimer's disease, and bone metabolic diseases. However, the regulatory roles of miRNAs in osteoporosis have not been systemati...

A deep-learning-based threshold-free method for automated analysis of rodent behavior in the forced swim test and tail suspension test.

Journal of neuroscience methods
BACKGROUND: The forced swim test (FST) and tail suspension test (TST) are widely used to assess depressive-like behaviors in animals. Immobility time is used as an important parameter in both FST and TST. Traditional methods for analyzing FST and TST...