Etiological stratification and prognostic assessment of haemophagocytic lymphohistiocytosis by machine learning on onco-mNGS data and clinical data.

Journal: Frontiers in immunology
PMID: 39315095

Abstract

INTRODUCTION: Hemophagocytic lymphohistiocytosis (HLH) is a rare, complicated and life threatening hyperinflammatory syndrome that maybe triggered by various infectious agents, malignancies and rheumatologic disorders. Early diagnosis and identification of the cause is essential to initiate appropriate treatment and improve the quality of life and survival of patients. The recently developed Onco-mNGS technology can be successfully used for simultaneous detection of infections and tumors.

Authors

  • Lin Wu
    Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University Chengdu 610039 China xingyage1@163.com.
  • Xuefang Cao
    Research and Development (R&D) Department, MatriDx Biotechnology Co., Ltd., Hangzhou, China.
  • Jingshi Wang
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Qi Kong
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Junxia Hu
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Lin Shi
    Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, China.
  • Liurui Dou
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Deli Song
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Leilei Chen
    Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science and Engineering, Zigong, China.
  • Mengyuan Zhou
    Department of Haematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
  • Huan Liu
    Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China.
  • Ruotong Ren
    Research and Development (R&D) Department, EBV-Care Biotechnology Co., Ltd., Beijing, China.
  • Zhao Wang
    Department of Urology, Xiangya Hospital, Central South University, Changsha, China.

Keywords

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