Diet-induced weight loss and markers of endothelial dysfunction and inflammation in treated patients with type 2 diabetes.

Journal: Clinical nutrition ESPEN
PMID: 28531772

Abstract

BACKGROUND & AIMS: Overweight and obesity increase cardiovascular mortality in patients with type 2 diabetes (T2D). In a recent trial, however, diet-induced weight loss did not reduce the cardiovascular risk of patients with T2D, possibly due to the parallel intensive medical treatment. We investigated the effect of diet-induced weight loss on cardiovascular risk factors in overweight and obese patients with T2D, and whether this effect was influenced by the use of statins, ACE inhibitors, metformin and duration of T2D.

Authors

  • K A Berk
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: k.berk@erasmusmc.nl.
  • T P Oudshoorn
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: tp.oudshoorn@gmail.com.
  • A J M Verhoeven
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: a.verhoeven@erasmusmc.nl.
  • M T Mulder
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: m.t.mulder@erasmusmc.nl.
  • A J M Roks
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: a.roks@erasmusmc.nl.
  • W A Dik
    Department of Immunology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: w.dik@erasmusmc.nl.
  • R Timman
    Department of Psychiatry, Section of Medical Psychology and Psychotherapy, Erasmus Medical Center, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: r.timman@erasmusmc.nl.
  • E J G Sijbrands
    Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, PO-Box 2040, 3000 CA, Rotterdam, The Netherlands. Electronic address: e.sijbrands@erasmusmc.nl.

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