Integrated multi-omics analysis and machine learning identify hub genes and potential mechanisms of resistance to immunotherapy in gastric cancer.

Journal: Aging
PMID:

Abstract

BACKGROUND: Patients with gastric cancer respond poorly to immunotherapy. There are still unknowns about the biomarkers associated with immunotherapy sensitivity and their underlying molecular mechanisms.

Authors

  • Jinsong Wang
    School of Computer and Communication Engineering, Tianjin University of Technology, Tianjin, China.
  • Jia Feng
    Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Sichuan Province Engineering Technology Research Center of Molecular Diagnosis of Clinical Diseases, Molecular Diagnosis of Clinical Diseases Key Laboratory of Luzhou, Sichuan, China.
  • Xinyi Chen
    School of Electronic and Electrical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China. Electronic address: c2257873708@163.com.
  • Yiming Weng
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
  • Tong Wang
    School of Public Health, Shanxi Medical University, Taiyuan 030000, China; Key Laboratory of Coal Environmental Pathogenicity and Prevention (Shanxi Medical University), Ministry of Education, Taiyuan 030000, China.
  • Jiayan Wei
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
  • Yujie Zhan
    Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China.
  • Min Peng
    Department of Dermatology, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China.