Serum Amyloid P-component Level May be a Biomarker for Lung Toxicities and Overall Survival after Thoracic Radiotherapy for Non-small Cell Lung Cancer.
Journal:
Clinical laboratory
PMID:
28164664
Abstract
BACKGROUND: Serum amyloid P-component (SAP) contributes to the clearance of apoptotic cells. As one of the main acute-phase reactants, SAP regulates key aspects of inflammation and sets a threshold for immune cell activation. This study aimed to investigate the association of SAP levels with symptomatic lung toxicities after thoracic radiotherapy (TRT) and overall survival (OS) in non-small lung cancer (NSCLC) patients.
Authors
Keywords
Biomarkers, Tumor
Carcinoma, Non-Small-Cell Lung
Enzyme-Linked Immunosorbent Assay
Humans
Kaplan-Meier Estimate
Lung Neoplasms
Multivariate Analysis
Predictive Value of Tests
Proportional Hazards Models
Pulmonary Fibrosis
Radiation Pneumonitis
Risk Factors
Serum Amyloid P-Component
Time Factors
Treatment Outcome