Histopathologic image-based deep learning classifier for predicting platinum-based treatment responses in high-grade serous ovarian cancer.

Journal: Nature communications
PMID: 38762636

Abstract

Platinum-based chemotherapy is the cornerstone treatment for female high-grade serous ovarian carcinoma (HGSOC), but choosing an appropriate treatment for patients hinges on their responsiveness to it. Currently, no available biomarkers can promptly predict responses to platinum-based treatment. Therefore, we developed the Pathologic Risk Classifier for HGSOC (PathoRiCH), a histopathologic image-based classifier. PathoRiCH was trained on an in-house cohort (n = 394) and validated on two independent external cohorts (n = 284 and n = 136). The PathoRiCH-predicted favorable and poor response groups show significantly different platinum-free intervals in all three cohorts. Combining PathoRiCH with molecular biomarkers provides an even more powerful tool for the risk stratification of patients. The decisions of PathoRiCH are explained through visualization and a transcriptomic analysis, which bolster the reliability of our model's decisions. PathoRiCH exhibits better predictive performance than current molecular biomarkers. PathoRiCH will provide a solid foundation for developing an innovative tool to transform the current diagnostic pipeline for HGSOC.

Authors

  • Byungsoo Ahn
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Damin Moon
    Artificial Intelligence Research Center, JLK Inc., Seoul, South Korea.
  • Hyun-Soo Kim
    Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
  • Chung Lee
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
  • Nam Hoon Cho
    Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea. cho1988@yuhs.ac.
  • Heung-Kook Choi
    Department of Computer Engineering, u-AHRC, Inje University, Gimhae, Gyeongsangnam, Korea.
  • Dongmin Kim
    JLK, Incorporated, Eonju-ro, Gangnam-gu, Seoul, South Korea.
  • Jung-Yun Lee
    Department of Obstetrics and Gynecology, Institute of Women's Life Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Eun Ji Nam
    Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei University College of Medicine, Seoul, Korea.
  • Dongju Won
    Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  • Hee Jung An
    Department of Pathology, CHA University, CHA Bundang Medical Center, Seongnam-si, Kyeonggi-do, Republic of Korea.
  • Sun Young Kwon
    Department of Pathology, Keimyung University School of Medicine, Dongsan Hospital, Daegu, Republic of Korea.
  • Su-Jin Shin
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Hye Ra Jung
    Department of Pathology, Keimyung University School of Medicine, Daegu, South Korea.
  • Dohee Kwon
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Heejung Park
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Milim Kim
    Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
  • Yoon Jin Cha
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Hyunjin Park
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Yangkyu Lee
    Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Songmi Noh
    Department of Diagnostic Pathology, Gangnam CHA Medical Center, CHA University College of Medicine, Seoul, South Korea.
  • Yong-Moon Lee
    Department of Pathology, Dankook University College of Medicine, Cheonan, Republic of Korea.
  • Sung-Eun Choi
    Department of Pathology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, Republic of Korea.
  • Ji Min Kim
    Department of Pathology, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
  • Sun Hee Sung
    Department of Pathology, Ewha Womans University, Seoul, South Korea.
  • Eunhyang Park
    Department of Pathology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

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