AIMC Topic: Platinum

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AI-Assisted Microfluidic Paper-Based Analytical Device with Au-Pt Nanoparticles for Multiplex, Interference-Resistant Quantification of Urinary Biomarkers.

Analytical chemistry
Urinary glucose, creatinine, and uric acid are vital biomarkers for diabetes and kidney disease management. However, multiplex point-of-care detection faces challenges due to insufficient sensitivity in complex urine matrices and signal cross-talk fr...

Synergistic Integration of Frequency-Dependent Impedance and Machine Learning in Semiconductor Metal Oxide-Based Breath Sensors for High-Performance Gas Discrimination.

ACS sensors
Frequency-dependent impedance spectroscopy in combination with machine learning offers a powerful strategy for discriminating among gas species using mutually interacting semiconductor metal oxide (SMO) gas sensors. In this study, 0.3 at% platinum-lo...

A Single-step Platinum Nanoparticle-Enhanced Lateral Flow Immunoassay Platform for Rapid Detection of Influenza A Virus.

ACS infectious diseases
Lateral flow immunoassays (LFIAs) are widely used point-of-care (POC) diagnostic tools, but their limited sensitivity can hinder reliable diagnoses. To address this limitation, we developed a novel POC diagnostic platform for the highly sensitive det...

Ligand Microenvironment-Regulated Nanozymes Enabled Machine Learning-Assisted Sensor Array for Simultaneous Identification of Phenolic Pollutants.

ACS sensors
Phenolic pollutants pose a great threat to human health due to high toxicity, whereas existing methods are difficult to achieve the rapid recognition of multiple phenolic pollutants. In this study, we developed a novel machine learning-assisted senso...

Microrobots for Antibiotic-Resistant Skin Colony Eradication.

ACS applied materials & interfaces
Self-propelled nano- and micromachines have immense potential as autonomous seek-and-act devices in biomedical applications. In this study, we present microrobots constructed with inherently biocompatible materials and propulsion systems tailored to ...

Split DNA Tetrahedron-Mediated Spatiotemporal-Hierarchy CRISPR Cascade Integrated with Au@Pt Nanolabels and Artificial Intelligence for a Cervical Cancer MicroRNA Bioassay.

ACS nano
The screening and monitoring of microRNAs as cancer molecular biomarkers is clinically significant, but traditional methods lack sufficient sensitivity, accuracy, and convenience. The CRISPR-colorimetric lateral flow assay (CLFA) integration offers a...

Addressing Hemolysis-Induced Loss of Sensitivity in Lateral Flow Assays of Blood Samples with Platinum-Coated Gold Nanoparticles and Machine Learning.

Analytical chemistry
Gold nanoparticles (GNPs), which appear red, are widely used as labels in lateral flow assays (LFAs) for visual detection. However, in blood-derived samples, hemolysis─caused by the rupture of red blood cells and the release of hemoglobin─creates a r...

Online OCHEM multi-task model for solubility and lipophilicity prediction of platinum complexes.

Journal of inorganic biochemistry
Predicting the solubility and lipophilicity of platinum(II, IV) complexes is essential for prioritizing potential anticancer candidates in drug discovery. This study introduces the first publicly available online model for predicting the solubility o...

Active Microrobots for Dual Removal of Biofilms via Chemical and Physical Mechanisms.

ACS applied materials & interfaces
Bacterial biofilms are complex multicellular communities that adhere firmly to solid surfaces. They are widely recognized as major threats to human health, contributing to issues such as persistent infections on medical implants and severe contaminat...

Smartphone-Assisted Nanozyme Colorimetric Sensor Array Combined "Image Segmentation-Feature Extraction" Deep Learning for Detecting Unsaturated Fatty Acids.

ACS sensors
Conventional methods for detecting unsaturated fatty acids (UFAs) pose challenges for rapid analyses due to the need for complex pretreatment and expensive instruments. Here, we developed an intelligent platform for facile and low-cost analysis of UF...