Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

Journal: American journal of rhinology & allergy

PMID: 28124643

Abstract

PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smooth-muscle actin [SMA]), extracellular matrix production, and collagen contraction in nasal polyp-derived fibroblasts (NPDF). The underlying molecular mechanisms of rapamycin were also determined in NPDFs.

Authors

Dong-Yn Ko

Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea This study was support.
Jae-Min Shin

Department of Otorhinolaryngology, Head and Neck Surgery, Seoul, South Korea.
Ji-Young Um
Byungjin Kang
Il-Ho Park
Heung-Man Lee

Keywords

Actins Cell Differentiation Cells, Cultured Collagen Extracellular Matrix Fibroblasts Humans Immunosuppressive Agents Myofibroblasts Nasal Polyps Phosphatidylinositol 3-Kinase RNA, Small Interfering Signal Transduction Sirolimus TOR Serine-Threonine Kinases Transforming Growth Factor beta

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View on PubMed Access via DOI PubMed (28124643)

Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

Abstract

Authors

Keywords

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