American journal of physiology. Cell physiology
38646782
Bleomycin (BLM)-induced lung injury in mice is a valuable model for investigating the molecular mechanisms that drive inflammation and fibrosis and for evaluating potential therapeutic approaches to treat the disease. Given high variability in the BL...
Forensic science, medicine, and pathology
38634992
The study investigated the relationship between the histological compositions of the tricuspid, pulmonary, mitral, and aortic valves, and age. All 85 fresh human hearts were obtained with an age range between 20 and 90 years. The central area of the ...
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
39180281
A U-Net machine learning algorithm was adapted to automatically segment tendon collagen fibril cross-sections from serial block face scanning electron microscopy (SBF-SEM) and create three-dimensional (3D) renderings. We compared the performance of r...
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
39271552
BACKGROUND: Accurate prediction of peritoneal recurrence for gastric cancer (GC) is crucial in clinic. The collagen alterations in tumor microenvironment affect the migration and treatment response of cancer cells. Herein, we proposed multitask machi...
Collagen, a key structural component of the extracellular matrix, undergoes significant remodeling during carcinogenesis. However, the important role of collagen levels in breast cancer diagnostics still lacks effective in vivo detection techniques t...
Real-time monitoring of gait characteristics is crucial for applications in health monitoring, patient rehabilitation feedback, and telemedicine. However, the effective and stable acquisition and automatic analysis of gait information remain signific...
Laboratory investigation; a journal of technical methods and pathology
39675724
Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining primarily reveals cellular inflammation with limited detail on f...
Biochemical changes in the cervix during labor are not well understood. This gap in knowledge is significant, as understanding the precise biochemical processes can provide critical insights into the mechanisms of labor and potentially inform better ...
Effective drug development for bone-related diseases, such as osteoporosis and metastasis, is hindered by the lack of physiologically relevant in vitro models. Traditional platforms, including standard tissue culture plastic, fail to replicate the st...
BACKGROUND AND OBJECTIVE: The dynamic evolution of collagen fibers during wound healing is crucial for assessing repair progression, guiding clinical treatment, and drug screening. Current quantitative methods analyzing collagen spatial patterns (den...