AIMC Topic: Collagen
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Quantitative ultrasound classification of healthy and chemically degraded ex-vivo cartilage.
Scientific reports
Jul 1, 2025
In this study, we explore the potential of ten quantitative (radiofrequency-based) ultrasound parameters to assess the progressive loss of collagen and proteoglycans, mimicking an osteoarthritis condition in ex-vivo bovine cartilage samples. Most ana...
Analysis of 2-dimensional regional differences in the peripapillary scleral fibroblast cytoskeleton of normotensive and hypertensive mouse eyes.
Scientific reports
Jul 1, 2025
These studies aimed to study the mechanisms of glaucomatous peripapillary scleral (PPS) remodeling by investigating IOP-induced changes in fibroblast actin-collagen alignment and nuclear morphology in mouse PPS. Cryosections from the optic nerve head...
Multivariate and Machine Learning-Derived Virtual Staining and Biochemical Quantification of Cancer Cells through Raman Hyperspectral Imaging.
Analytical chemistry
Jun 11, 2025
Advances in virtual staining and spatial omics have revolutionized our ability to explore cellular architecture and molecular composition with unprecedented detail. Virtual staining techniques, which rely on computational algorithms to map molecular ...
Machine learning combined with infrared spectroscopy for detection of hypertension pregnancy: towards newborn and pregnant blood analysis.
BMC pregnancy and childbirth
Mar 27, 2025
Biochemical changes in the cervix during labor are not well understood. This gap in knowledge is significant, as understanding the precise biochemical processes can provide critical insights into the mechanisms of labor and potentially inform better ...
AI-Assisted Label-Free Monitoring Bone Mineral Metabolism on Demineralized Bone Paper.
ACS biomaterials science & engineering
Mar 19, 2025
Effective drug development for bone-related diseases, such as osteoporosis and metastasis, is hindered by the lack of physiologically relevant in vitro models. Traditional platforms, including standard tissue culture plastic, fail to replicate the st...
Diagnosis of Fibrotic Interstitial Lung Diseases Based on the Combination of Label-Free Quantitative Multiphoton Fiber Histology and Machine Learning.
Laboratory investigation; a journal of technical methods and pathology
Dec 13, 2024
Interstitial lung disease (ILD), characterized by inflammation and fibrosis, often suffers from low diagnostic accuracy and consistency. Traditional hematoxylin and eosin (H&E) staining primarily reveals cellular inflammation with limited detail on f...
Detecting Collagen by Machine Learning Improved Photoacoustic Spectral Analysis for Breast Cancer Diagnostics: Feasibility Studies With Murine Models.
Journal of biophotonics
Nov 26, 2024
Collagen, a key structural component of the extracellular matrix, undergoes significant remodeling during carcinogenesis. However, the important role of collagen levels in breast cancer diagnostics still lacks effective in vivo detection techniques t...
Leather-Based Shoe Soles for Real-Time Gait Recognition and Automatic Remote Assistance Using Machine Learning.
ACS applied materials & interfaces
Nov 1, 2024
Real-time monitoring of gait characteristics is crucial for applications in health monitoring, patient rehabilitation feedback, and telemedicine. However, the effective and stable acquisition and automatic analysis of gait information remain signific...
Multitask machine learning-based tumor-associated collagen signatures predict peritoneal recurrence and disease-free survival in gastric cancer.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Sep 14, 2024
BACKGROUND: Accurate prediction of peritoneal recurrence for gastric cancer (GC) is crucial in clinic. The collagen alterations in tumor microenvironment affect the migration and treatment response of cancer cells. Herein, we proposed multitask machi...
Neural network auto-segmentation of serial-block-face scanning electron microscopy images exhibit collagen fibril structural differences with tendon type and health.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Aug 23, 2024
A U-Net machine learning algorithm was adapted to automatically segment tendon collagen fibril cross-sections from serial block face scanning electron microscopy (SBF-SEM) and create three-dimensional (3D) renderings. We compared the performance of r...
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