AIMC Topic: Phosphatidylinositol 3-Kinase

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Modulatory role of garlicin in migration and invasion of intrahepatic cholangiocarcinoma via PI3K/AKT pathway.

International journal of clinical and experimental pathology Nov 1, 2015
Increasing evidences have indicated the role of garlicin in inhibiting the progression of various tumors including glioma, pulmonary carcinoma and pancreatic carcinoma, via mediating cell apoptosis or cell cycle. The regulatory effect and related mol...
Humans Cell Line, Tumor Cell Proliferation Signal Transduction Cell Movement Neoplasm Invasiveness Dose-Response Relationship, Drug Antineoplastic Agents, Phytogenic Phosphorylation Proto-Oncogene Proteins c-akt Bile Duct Neoplasms Disulfides Allyl Compounds Protein Kinase Inhibitors Cholangiocarcinoma Phosphatidylinositol 3-Kinase Phosphoinositide-3 Kinase Inhibitors
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Rapamycin inhibits transforming growth factor beta 1 induced myofibroblast differentiation via the phosphorylated-phosphatidylinositol 3-kinase mammalian target of rapamycin signal pathways in nasal polyp-derived fibroblasts.

American journal of rhinology & allergy Nov 1, 2016
PURPOSE: Rapamycin has antiproliferative and antifibrogenic effects in vitro and in vivo. The purpose of this study was to evaluate the effects of rapamycin on transforming growth factor (TGF) beta 1 induced myofibroblast differentiation (alpha smoot...
Humans Cells, Cultured Signal Transduction Fibroblasts Immunosuppressive Agents Myofibroblasts Nasal Polyps Cell Differentiation Transforming Growth Factor beta TOR Serine-Threonine Kinases RNA, Small Interfering Collagen Extracellular Matrix Actins Phosphatidylinositol 3-Kinase Sirolimus
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