Decoding temporal heterogeneity in NSCLC through machine learning and prognostic model construction.

Journal: World journal of surgical oncology
Published Date: Jun 13, 2024

Abstract

BACKGROUND: Non-small cell lung cancer (NSCLC) is a prevalent and heterogeneous disease with significant genomic variations between the early and advanced stages. The identification of key genes and pathways driving NSCLC tumor progression is critical for improving the diagnosis and treatment outcomes of this disease.

Authors

  • Junpeng Cheng
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Meizhu Xiao
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Qingkang Meng
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Min Zhang
    Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Denan Zhang
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Lei Liu
    Department of Science and Technology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
  • Qing Jin
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Zhijin Fu
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Yanjiao Li
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China.
  • Xiujie Chen
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China. chenxiujie@ems.hrbmu.edu.cn.
  • Hongbo Xie
    Department of Pharmacogenomics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150086, P. R. China. xiehongbo@ems.hrbmu.edu.cn.

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