Methods (San Diego, Calif.)
Mar 12, 2024
N6-methyladenosine (m6A) is the most prevalent, abundant, and conserved internal modification in the eukaryotic messenger RNA (mRNAs) and plays a crucial role in the cellular process. Although more than ten methods were developed for m6A detection ov...
Methods (San Diego, Calif.)
Jan 28, 2024
The accurate identification of drug-protein interactions (DPIs) is crucial in drug development, especially concerning G protein-coupled receptors (GPCRs), which are vital targets in drug discovery. However, experimental validation of GPCR-drug pairin...
Methods (San Diego, Calif.)
Jan 26, 2024
MicroRNAs (miRNAs) are vital in regulating gene expression through binding to specific target sites on messenger RNAs (mRNAs), a process closely tied to cancer pathogenesis. Identifying miRNA functional targets is essential but challenging, due to in...
Methods (San Diego, Calif.)
Jan 17, 2024
DNA-binding proteins are a class of proteins that can interact with DNA molecules through physical and chemical interactions. Their main functions include regulating gene expression, maintaining chromosome structure and stability, and more. DNA-bindi...
Methods (San Diego, Calif.)
Jan 4, 2024
The interaction between human microbes and drugs can significantly impact human physiological functions. It is crucial to identify potential microbe-drug associations (MDAs) before drug administration. However, conventional biological experiments to ...
Methods (San Diego, Calif.)
Dec 21, 2023
The International Classification of Diseases (ICD) serves as a global healthcare administration standard, with one of its editions being ICD-10-CM, an enhanced diagnostic classification system featuring numerous new codes for specific anatomic sites,...
Methods (San Diego, Calif.)
Oct 27, 2023
Influenza viruses are detected year-round over the world and the viruses will usually circulate during fall and winter, causing the seasonal flu. The growing novel variants of influenza viruses pose a significant concern to public health annually. Ho...
Methods (San Diego, Calif.)
Oct 21, 2023
Secondary active transporters play pivotal roles in regulating ion and molecule transport across cell membranes, with implications in diseases like cancer. However, studying transporters via biochemical experiments poses challenges. We propose an eff...
Methods (San Diego, Calif.)
Sep 29, 2023
Artificial intelligence (AI), particularly deep learning as a subcategory of AI, provides opportunities to accelerate and improve the process of discovering and developing new drugs. The use of AI in drug discovery is still in its early stages, but i...
Methods (San Diego, Calif.)
Sep 9, 2023
Heart rate variability (HRV) is an important indicator of autonomic nervous system activity and can be used for the identification of affective states. The development of remote Photoplethysmography (rPPG) technology has made it possible to measure p...