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Non-invasive regional cerebral blood flow quantification in the 123I-IMP autoradiography using artificial neural network.

PloS one 36888603

PURPOSE: Regional cerebral blood flow (rCBF) quantification using 123I-N-isopropyl-p-iodoamphetamine (123I-IMP) requires an invasive, one-time-only arterial blood sampling for measuring the 123I-IMP arterial blood radioactivity concentration (Ca10). ...

Amphetamines Autoradiography Brain Cerebrovascular Circulation Humans Iofetamine Neural Networks, Computer Regional Blood Flow Retrospective Studies Tomography, Emission-Computed, Single-Photon

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Assessing the effects of 5-HT and 5-HT receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms.

Pharmacological reports : PR 39602080

BACKGROUND: Serotonergic psychedelics, which display a high affinity and specificity for 5-HT receptors like 2,5-dimethoxy-4-iodoamphetamine (DOI), reliably induce a head-twitch response in rodents characterized by paroxysmal, high-frequency head rot...

Algorithms Amphetamines Animals Deep Learning Dose-Response Relationship, Drug Hallucinogens Head Movements Male Rats Receptor, Serotonin, 5-HT2A Serotonin 5-HT2 Receptor Antagonists Serotonin Antagonists

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Amphetamines

Non-invasive regional cerebral blood flow quantification in the 123I-IMP autoradiography using artificial neural network.

Assessing the effects of 5-HT and 5-HT receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms.

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