Ecotoxicology and environmental safety
Aug 1, 2025
BACKGROUND: Exposure to heavy metals represents a significant risk factor for hypertension and blood pressure disorders. Notably, current evidence indicates that the key biological processes of oxidative stress, inflammation, and endothelial dysfunct...
PI3Kγ is a lipid kinase that is expressed primarily in leukocytes and plays a significant role in tumors, inflammation, and autoimmune diseases. Consequently, considerable attention has been given to the development of pharmacological inhibitors of P...
Converting cellulose into 5-Hydroxymethylfurfural (HMF) provides a promising strategy for creating bio-based chemicals, offering sustainable alternatives to petroleum-based materials in polymers, biofuels, and pharmaceuticals. However, the efficient ...
International journal of medical informatics
Aug 1, 2025
BACKGROUND: In light of global population aging and the increasing prevalence of Rheumatoid Arthritis (RA) with age, strategies are needed to address this public health challenge. Machine learning (ML) may play a vital role in early identification of...
Journal of chemical information and modeling
Jul 14, 2025
The binding of zinc ions to proteins plays a crucial role in normal physiological functions and life activities of organisms. To enhance the prediction accuracy of zinc-binding protein interaction sites, the paper proposes a novel hybrid deep predict...
Journal of chemical information and modeling
Jul 14, 2025
Machine learning (ML) has emerged as a transformative tool in material science, enabling accelerated discovery and design of novel molecules while reducing experimental costs. Uncertainty quantification (UQ) is crucial for enhancing the reliability o...
The analysis of high-dimensional microbiome multiomics datasets is crucial for understanding the complex interactions between microbial communities and host physiological states across health and disease conditions. Despite their importance, current ...
MOTIVATION: Drug side effects refer to harmful or adverse reactions that occur during drug use, unrelated to the therapeutic purpose. A core issue in drug side effect prediction is determining the frequency of these drug side effects in the populatio...
In longitudinal observational studies with time-varying confounders, the generalized computation algorithm formula (g-formula) is a principled tool to estimate the average causal effect of a treatment regimen. However, the standard non-iterative g-fo...
There are challenges involving human resource management, as the selection and evaluation processes for nursing diagnostic labels are time-consuming, resulting in an excessive workload. This, in turn, can lead to insufficient attention being given to...
Join thousands of healthcare professionals staying informed about the latest AI breakthroughs in medicine. Get curated insights delivered to your inbox.