AIMC Topic: Cell Movement

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Identification and validation of HOXC6 as a diagnostic biomarker for Ewing sarcoma: insights from machine learning algorithms and experiments.

Frontiers in immunology
INTRODUCTION: Early diagnosis of Ewing sarcoma (ES) is critical for improving patient prognosis. However, the accurate diagnosis of ES remains challenging, underscoring the need for novel diagnostic biomarkers to enhance diagnostic precision and reli...

Spatiotemporal feature learning for actin dynamics.

PloS one
The social amoeba Dictyostelium discoideum is a standard model system for studying cell motility and formation of biological patterns. D. discoideum cells form protrusions and migrate via cytoskeletal reorganization driven by coordinated waves of act...

Big data analysis and machine learning of the role of cuproptosis-related long non-coding RNAs (CuLncs) in the prognosis and immune landscape of ovarian cancer.

Frontiers in immunology
BACKGROUND: Ovarian cancer (OC) is a severe malignant tumor with a significant threat to women's health, characterized by a high mortality rate and poor prognosis despite conventional treatments such as cytoreductive surgery and platinum-based chemot...

Machine Learning Identification and Classification of Mitosis and Migration of Cancer Cells in a Lab-on-CMOS Capacitance Sensing Platform.

IEEE journal of biomedical and health informatics
Cell culture assays play a vital role in various fields of biology. Conventional assay techniques like immunohistochemistry, immunofluorescence, and flow cytometry offer valuable insights into cell phenotype and behavior. However, each of these techn...

Opioid growth factor receptor overexpression exerts anti-hepatocellular carcinoma effects by activating P16 and P21 to inhibit proliferation and migration of HepG2 cells.

Folia histochemica et cytobiologica
INTRODUCTION: Hepatocellular carcinoma (HCC) is the sixth most common type of cancer and the second leading cause of cancer death worldwide [19]. Opioid growth factor (OGF) has been shown to exhibit antitumour potential, binding to OGF receptor (OGFr...

PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation.

BMC cancer
BACKGROUND: Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great significance. In our previous study, we found that prenylated rab acceptor 1 domain family member 2 (PRAF2) is an oncogene in ...

A data-driven approach to establishing cell motility patterns as predictors of macrophage subtypes and their relation to cell morphology.

PloS one
The motility of macrophages in response to microenvironment stimuli is a hallmark of innate immunity, where macrophages play pro-inflammatory or pro-reparatory roles depending on their activation status during wound healing. Cell size and shape have ...

CXCL12 impact on glioblastoma cells behaviors under dynamic culture conditions: Insights for developing new therapeutic approaches.

PloS one
Glioblastoma multiforme (GBM) is the most prevalent malignant brain tumor, with an average survival time of 14 to 20 months. Its capacity to invade brain parenchyma leads to the failure of conventional treatments and subsequent tumor recurrence. Rece...

Effects of aqueous and ethanolic extracts of Chinese propolis on dental pulp stem cell viability, migration and cytokine expression.

PeerJ
BACKGROUND: Propolis is a natural substance produced by honeybees that has various biological properties including, anti-inflammatory, antioxidant and antimicrobial properties. Although previous studies have evaluated the antimicrobial effects of pro...