Cell sorting, essential for diagnostics and early intervention, has evolved from conventional methods to sophisticated microfluidic approaches. These miniaturized systems leverage precise hydrodynamic control, facilitating major advances in tumor cel...
Cell separation is a critical step in many assays in biomedical research, diagnostics, and drug development. Here, we developed VibroMag, a vibration-assisted magnetic cell separation technology specifically designed for automated processing of stand...
Partitioning cells in open nanowells permits high confidence in single cell occupancy and enables flexibility in the development of different molecular assays. A challenge for this approach however is to print cells sufficiently quickly to enable exp...
Current cell sorting methods often lack versatility, require complex setups, demand large initial cell numbers for reliable sorting, and impose size limitations on target objects. To address these challenges, we introduce two-dimensional sorting with...
The precise separation and focusing of circulating tumor cells (CTCs) from blood cells are crucial for advancing cancer diagnosis, optimizing therapeutic strategies, and fostering progress in cellular research. Inertial microfluidics offers an effici...
Imaging flow cytometry allows image-activated cell sorting (IACS) with enhanced feature dimensions in cellular morphology, structure, and composition. However, existing IACS frameworks suffer from the challenges of 3D information loss and processing ...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Nov 5, 2024
Sorting specific cells from heterogeneous samples is important for research and clinical applications. In this work, a novel label-free cell sorting method is presented that integrates deep learning image recognition with microfluidic manipulation to...
Metastatic tumors have poor prognoses for progression-free and overall survival for all cancer patients. Rare circulating tumor cells (CTCs) and rarer circulating tumor cell clusters (CTCCs) are potential biomarkers of metastatic growth, with CTCCs r...
Cells are the singular building blocks of life, and a comprehensive understanding of morphology, among other properties, is crucial to the assessment of underlying heterogeneity. We developed Computational Sorting and Mapping of Single Cells (COSMOS)...
Mathematical biosciences and engineering : MBE
Dec 14, 2022
Single cell dispensing techniques mainly include limiting dilution, fluorescent-activated cell sorting (FACS) and microfluidic approaches. Limiting dilution process is complicated by statistical analysis of clonally derived cell lines. Flow cytometry...
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