AIMC Topic: Cell Surface Display Techniques

Clear Filters Showing 1 to 5 of 5 articles

Discovery and affinity maturation of antibody fragments from an unfavorably enriched phage display selection by deep sequencing and machine learning.

Journal of bioscience and bioengineering Jun 4, 2025
Phage display selection has been used for directed evolution of antibody fragments. However, variants with binding affinity cannot be always identified due to undesirable enrichment of target-unrelated variants in the biopanning process. Here, our go...
Humans Machine Learning Peptide Library High-Throughput Nucleotide Sequencing Bacteriophages Antibody Affinity Immunoglobulin Fragments Cell Surface Display Techniques
View on PubMed DOI

A new strategy to HER2-specific antibody discovery through artificial intelligence-powered phage display screening based on the Trastuzumab framework.

Biochimica et biophysica acta. Molecular basis of disease Mar 7, 2025
Human epidermal growth factor receptor 2 (HER2) is a recognized drug target, and it serves as a critical target for various cancer treatments, necessitating the discovery of more antibodies for therapeutic and detection purposes. Here, we have develo...
Humans Artificial Intelligence Peptide Library Receptor, ErbB-2 Trastuzumab Cell Surface Display Techniques
View on PubMed DOI

Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization.

Journal of nanobiotechnology Feb 6, 2025
Nanobodies (Nbs), miniature antibodies consisting solely of the variable region of heavy chains, exhibit unique properties such as small size, high stability, and strong specificity, making them highly promising for disease diagnosis and treatment. T...
Humans Artificial Intelligence Animals Peptide Library Single-Domain Antibodies Protein Engineering Cell Surface Display Techniques
View on PubMed DOI

Phage display enables machine learning discovery of cancer antigen-specific TCRs.

Science advances Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
Humans Machine Learning Neoplasms Epitopes, T-Lymphocyte Receptors, Antigen, T-Cell Peptide Library Antigens, Neoplasm Membrane Proteins Cell Surface Display Techniques
View on PubMed DOI

Efficient Design of Affilin Protein Binders for HER3.

International journal of molecular sciences May 14, 2025
Engineered scaffold-based proteins that bind to concrete targets with high affinity offer significant advantages over traditional antibodies in theranostic applications. Their development often relies on display methods, where large libraries of vari...
Humans Protein Binding Peptide Library Ligands Protein Engineering Receptor, ErbB-3 Cell Surface Display Techniques
View on PubMed DOI
Popular Topics
Recent Journals