AIMC Topic: Cell Surface Display Techniques
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A new strategy to HER2-specific antibody discovery through artificial intelligence-powered phage display screening based on the Trastuzumab framework.
Biochimica et biophysica acta. Molecular basis of disease
Mar 7, 2025
Human epidermal growth factor receptor 2 (HER2) is a recognized drug target, and it serves as a critical target for various cancer treatments, necessitating the discovery of more antibodies for therapeutic and detection purposes. Here, we have develo...
Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization.
Journal of nanobiotechnology
Feb 6, 2025
Nanobodies (Nbs), miniature antibodies consisting solely of the variable region of heavy chains, exhibit unique properties such as small size, high stability, and strong specificity, making them highly promising for disease diagnosis and treatment. T...
Phage display enables machine learning discovery of cancer antigen-specific TCRs.
Science advances
Jun 13, 2025
T cells targeting epitopes in infectious diseases or cancer play a central role in spontaneous and therapy-induced immune responses. Epitope recognition is mediated by the binding of the T cell receptor (TCR), and TCRs recognizing clinically relevant...
Efficient Design of Affilin Protein Binders for HER3.
International journal of molecular sciences
May 14, 2025
Engineered scaffold-based proteins that bind to concrete targets with high affinity offer significant advantages over traditional antibodies in theranostic applications. Their development often relies on display methods, where large libraries of vari...
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