AIMC Topic: Immunoglobulin Fragments

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Discovery and affinity maturation of antibody fragments from an unfavorably enriched phage display selection by deep sequencing and machine learning.

Journal of bioscience and bioengineering Jun 4, 2025
Phage display selection has been used for directed evolution of antibody fragments. However, variants with binding affinity cannot be always identified due to undesirable enrichment of target-unrelated variants in the biopanning process. Here, our go...
Humans Machine Learning Peptide Library High-Throughput Nucleotide Sequencing Bacteriophages Antibody Affinity Immunoglobulin Fragments Cell Surface Display Techniques
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Surface Adsorbed Antibody Characterization Using ToF-SIMS with Principal Component Analysis and Artificial Neural Networks.

Langmuir : the ACS journal of surfaces and colloids Aug 19, 2016
Artificial neural networks (ANNs) form a class of powerful multivariate analysis techniques, yet their routine use in the surface analysis community is limited. Principal component analysis (PCA) is more commonly employed to reduce the dimensionality...
Humans Neural Networks, Computer Immunoglobulin G Animals Adsorption Principal Component Analysis Amino Acids Antibodies Multivariate Analysis ErbB Receptors Immunoglobulin Fragments Spectrometry, Mass, Secondary Ion
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